20980-00-1

Basic information

• Product Name: N-(4-bromophenyl)ethanethioamide
• CAS NO: 20980-00-1
• Molecular Formula: C₈H₈BrNS
• Molecular Weight: 230.1248
• Mol File: 20980-00-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 276.4°C at 760 mmHg
• Flash Point: 120.9°C
• Density: 1.57g/cm³
• Vapor Pressure: 0.00482mmHg at 25°C
• Refractive Index: 1.681
• CAS DataBase Reference: N-(4-bromophenyl)ethanethioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromophenyl)ethanethioamide(20980-00-1)
• EPA Substance Registry System: N-(4-bromophenyl)ethanethioamide(20980-00-1)

Safety Data

• Hazardous Substances Data: 20980-00-1(Hazardous Substances Data)

Upstream product

• 103-88-8 4-bromoacetanilide 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 59862-55-4 (E)-1-(4-bromophenyl)ethan-1-one oxime 
• 917-54-4 methyllithium 
• 59862-55-4 p-bromoacetophenone oxime 
• 861795-98-4 ethyl 2-((4-bromophenyl)carbamothioyl)-3-oxobutanoate 
• 75-36-5 acetyl chloride 
• 106-40-1 4-bromo-aniline 
• 98-09-9 benzenesulfonyl chloride 
• 861797-02-6 N-(4-bromo-phenyl)-3-thio-malonamic acid 

Downstream Products

• 5304-21-2 6-bromo-2-methylbenzothiazole 
• 98437-33-3 1-(4'-bromophenyl)-5-methyl-1H-tetrazole 
• 103-88-8 4-bromoacetanilide 

Relevant articles and documents

Dehydrative Beckmann rearrangement and the following cascade reactions

The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam. By strategically using the in situ generated Appel's salt or Mitsunobu's zwitterionic adduct as the dehydrating agent, a series of Beckmann rearrangement and following cascade reactions have been developed herein. The protocol allows the conversion of various ketoximes into amide, thioamide, tetrazole and imide products in modular procedures. The generality and tolerance of functionalities of this method have been demonstrated.

Facile synthesis of thioamides via P2S5-mediated beckmann rearrangement of oximes

A facile and efficient approach to the synthesis of secondary thioamides from ketoximes via Beckmann rearrangement has been established, using phosphorus pentasulfide as a dehydrating and thiating agent. It is also efficient for the preparation of primary thiobenzamide from benzaldoxime. This approach features simple-operation, easy-control and good to excellent yields.