209861-02-9

Basic information

• Product Name: TF-Diol
• Synonyms: TF-Diol;(3aR,4R,5R,6aS)-4-((1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol (TF-Diol);2H-Cyclopenta[b]furan-2,5-diol,4-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]hexahydro-(3aR,4R,5R,6aS)-;(3aR,4R,5R,6aS)-4-[(1E)-3,3-Difluoro-4-phenoxy-1-butenyl]hexahydro-2H-cyclopenta[b]furan-2,5-diol;TF-DI
• CAS NO: 209861-02-9
• Molecular Formula: C₁₇H₂₀F₂O₄
• Molecular Weight: 326.3351064
• Mol File: 209861-02-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 481.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.361±0.06 g/cm3(Predicted)
• PKA: 13.01±0.60(Predicted)
• CAS DataBase Reference: TF-Diol(CAS DataBase Reference)
• NIST Chemistry Reference: TF-Diol(209861-02-9)
• EPA Substance Registry System: TF-Diol(209861-02-9)

Safety Data

• Hazardous Substances Data: 209861-02-9(Hazardous Substances Data)

Usage

General Description

TF-Diol is a synthetic chemical compound consisting of a diol, or two hydroxyl groups, attached to a trifluoromethyl group. It is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and advanced materials due to its unique physical and chemical properties. TF-Diol is known for its high stability and resistance to degradation, as well as its ability to modify the reactivity and selectivity of other chemical compounds. It is also valued for its potential applications in organic synthesis and medicinal chemistry, making it a versatile and important chemical in the field of drug development and material science.

Upstream product

• 163074-98-4 [(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde] 
• 81190-06-9 [(3aR,4S,5R,6aS)-hexahydro-4-(hydroxymethyl)-5-(phenylmethoxy)-2H-cyclopenta[b]furan-2-one] 
• 209861-00-7 (3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybutan-1-en-1-yl)-hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl benzoate 
• 51638-91-6 (3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate 
• 209861-01-8 (3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one 
• 29782-85-2 rac-(trans)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-ol 
• 1487-05-4 rac-(trans)-3,3-dimethyltetrahydro-5H-oxireno[2',3':3,4]cyclopenta[1,2-d][1,3]dioxole 
• 5623-52-9 rac-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxole 

Downstream Products

• 209860-87-7 tafluprost 
• 209860-89-9 1-(5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenylamino-1-butenyl]-dihydroxycyclopentyl}-5-ethylheptenoate 
• 1449413-13-1 C₂₂H₂₈F₂O₅*C₁₂H₂₃N 
• 209860-88-8 AFP-172 

Relevant articles and documents

Method for large-scale preparation of tafluprost

The invention discloses a method for industrially preparing tafluprost. The method comprises the following steps: taking Corey lactone as an initial raw material, oxidizing, condensing, fluorinating,deprotecting, reducing, re-condensing, esterifying and r

METHOD OF PURIFICATION OF PROSTAGLANDINS INCLUDING FLUORINE ATOMS BY PREPARATIVE HPLC

The present invention discloses a method of purification of prostaglandins including fluorine atoms by using preparative HPLC. Tafluprost and Travoprost are prostaglandins including fluorine. The chemical structure of the impurities in crude Tafluprost an

Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: A novel 15-deoxy-15,15-difluoroprostaglandin F2α derivative

A novel 15-deoxy-15,15-difluoro-prostaglandin(PG)F2α derivative 6 (AFP-168) has been synthesized from the Corey aldehyde in six steps. A key aspect of this route is difluorination of an enone and a stereoselective Wittig reaction. The compound shows high affinity to the FP receptor and potent activities for an anti-glaucoma agent.