20989-42-8

Basic information

• Product Name: L-Serine, N-benzoyl-, methyl ester
• Synonyms: N-benzoylserine methyl ester;N-benzoyl-L-serine methyl ester;N-benzoyl-(S)-serine methyl ester;(S)-N-1-(1-carbomethoxy-2-hydroxyethyl)benzenecarboxamide;(S)-methyl 2-benzamido-3-hydroxypropanoate;Bz-Ser-OMe
• CAS NO: 20989-42-8
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• Mol File: 20989-42-8.mol
• Article Data: 29

Chemical Properties

• Melting Point: 84-85 °C
• Boiling Point: 474.3±35.0 °C(Predicted)
• Density: 1.235±0.06 g/cm3(Predicted)
• CAS DataBase Reference: L-Serine, N-benzoyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Serine, N-benzoyl-, methyl ester(20989-42-8)
• EPA Substance Registry System: L-Serine, N-benzoyl-, methyl ester(20989-42-8)

Safety Data

• Hazardous Substances Data: 20989-42-8(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 4582-71-2 benzoyl-DL-serine 
• 67-56-1 methanol 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 98-88-4 benzoyl chloride 
• 2788-84-3 (S)-serine methyl ester 
• 65-85-0 benzoic acid 
• 4877-23-0 (S)-2-benzoylamino-3-hydroxypropionic acid 
• 903566-73-4 [1S,2S,6S,7S]-1,6-diaza-4,9-dioxa-2,7-dimethoxycarbonylbicyclo[4.4.1]undecane 
• 5619-04-5 methyl 2-amino-3-hydroxypropanoate hydrochloride 

Downstream Products

• 121713-49-3 2-Benzoylamino-3-chloromethoxy-propionic acid methyl ester 
• 24153-31-9 2-benzoylaminoacrylic acid methyl ester 
• 1137241-59-8 N-benzoyl-O-tritylserine methyl ester 
• 497260-34-1 benzoylamino-(3-iodo-4-methoxy-phenyl)-acetic acid methyl ester 
• 698372-49-5 O-(3,4,6-tri-O-benzyl-2-deoxy-2-nitro-β-D-galactopyranosyl)-N-(benzoyl)-L-serine methyl ester 
• 59171-72-1 2-phenyl-oxazole-4-carboxylic acid methyl ester 
• 55044-06-9 methyl 2-phenyl-2-oxazoline-4-carboxylate 
• 128254-51-3 dimethyl 2,5-dibenzamido-3-oxahexanedioate 
• 4877-23-0 (S)-2-benzoylamino-3-hydroxypropionic acid 
• 864954-18-7 C₃H₄O₄*C₆H₁₄N₄O₂*C₁₇H₁₈N₂O₃ 
• 864954-10-9 (cis)-2-(p-aminophenyl)-5-benzoylamino-1,3-dioxane 
• 864954-02-9 cis-N-[2-(4'-nitrophenyl)-1,3-dioxan-5-yl]benzamide 
• 110339-41-8 methyl (acetyloxy)(benzoylamino)acetate 

Relevant articles and documents

Metal-Free Selective Modification of Secondary Amides: Application in Late-Stage Diversification of Peptides

Here we solve a long-standing challenge of the site-selective modification of secondary amides and present a simple two-step, metal-free approach to selectively modify a particular secondary amide in molecules containing multiple primary and secondary amides. Density functional theory (DFT) provides insight into the activation of C-N bonds. This study encompasses distinct chemical advances for late-stage modification of peptides thus harnessing the amides for the incorporation of various functional groups into natural and synthetic molecules.

Synthesis method of ramipril key intermediate

The invention discloses a synthesis method of a ramipril key intermediate. The ramipril key intermediate is 2-azabicyalo [3.3.0] octane-3-carboxylic acid hydrochloride. The 2-azabicyalo [3.3.0] octane-3-carboxylic acid hydrochloride is obtained through sequential dehydration cyclization, formaldehyde condensation, hydrolysis, removal, Michael addition, cyclization and palladium-carbon catalytic hydrogenation reduction of N-benzoyl-glycine as a raw material. According to the synthesis method of the ramipril key intermediate, the required raw material and reagent are cheap and available, the yield is relatively high, the operation is simple, the cost is low and the method is suitable for industrial production.

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor. The