20996-87-6 Usage
General Description
1-Methyl-1H-indole-6-carbonitrile is a chemical compound with the formula C10H8N2. It is a derivative of indole, a heterocyclic aromatic organic compound. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It plays a crucial role in the production of various drugs, including antiviral and anticancer agents. Additionally, 1-methyl-1H-indole-6-carbonitrile is used as a building block in organic synthesis, particularly in the formation of carbon-carbon and carbon-nitrogen bonds. It is an important chemical in the field of medicinal chemistry and drug development due to its versatile reactivity and biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 20996-87-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,9,9 and 6 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 20996-87:
(7*2)+(6*0)+(5*9)+(4*9)+(3*6)+(2*8)+(1*7)=136
136 % 10 = 6
So 20996-87-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H8N2/c1-12-5-4-9-3-2-8(7-11)6-10(9)12/h2-6H,1H3
20996-87-6Relevant articles and documents
Nickel-catalyzed cyanation of aryl halides and triflates using acetonitrile: Via C-CN bond cleavage assisted by 1,4-bis(trimethylsilyl)-2,3,5,6-tetramethyl-1,4-dihydropyrazine
Ueda, Yohei,Tsujimoto, Nagataka,Yurino, Taiga,Tsurugi, Hayato,Mashima, Kazushi
, p. 994 - 999 (2019/02/03)
We developed a non-toxic cyanation reaction of various aryl halides and triflates in acetonitrile using a catalyst system of [Ni(MeCN)6](BF4)2, 1,10-phenanthroline, and 1,4-bis(trimethylsilyl)-2,3,5,6-tetramethyl-1,4-dihydropyrazine (Si-Me4-DHP). Si-Me4-DHP was found to function as a reductant for generating nickel(0) species and a silylation reagent to achieve the catalytic cyanation via C-CN bond cleavage.
The design and synthesis of a novel series of indole derived selective ETA antagonists
Rawson, David J.,Dack, Kevin N.,Dickinson, Roger P.,James, Kim
, p. 125 - 128 (2007/10/03)
Conformational constraint has been used as the key design element in the identification of a series of potent and selective ETA antagonists. The most potent antagonist, 32, (ETA IC50 = 0.55 nM) is 722-fold selective over t
