209977-56-0

Basic information

• Product Name: (r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4 -yl]-propionic Acid Sesquihydrate
• Synonyms: (+/-)-2-Amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propanoic acid sesquihydrate;α-AMino-3-(carboxyMethoxy)-5-Methyl-4-isoxazolepropanoic Acid Hydrate (2:3);2-Amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionic acid sesquihydrate, 2-Amino-3-[3-(carboxymethoxy)-5-methyl-1,2-oxazol-4-yl]propanoic acid sesquihydrate
• CAS NO: 209977-56-0
• Molecular Formula: C18H30N4O15
• Molecular Weight: 542.4486
• Product Categories: Amino Acids & Derivatives;Heterocycles;Neurochemicals
• Mol File: 209977-56-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 230°C dec.
• Appearance: /
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Stability: Store in freezer at -20°C
• CAS DataBase Reference: (r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4 -yl]-propionic Acid Sesquihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: (r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4 -yl]-propionic Acid Sesquihydrate(209977-56-0)
• EPA Substance Registry System: (r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4 -yl]-propionic Acid Sesquihydrate(209977-56-0)

Safety Data

• Hazardous Substances Data: 209977-56-0(Hazardous Substances Data)

Usage

Description

(r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4-yl]-propionic Acid Sesquihydrate is a white crystalline solid that serves as a selective inhibitor of [3H]-AMPA binding in rat brain membranes. It exhibits minimal affinity for [3H]-kainate binding sites or other sites on the NMDA receptor-channel complex, as indicated by the binding of [3H]-CPP, [3H]-gly, or [3H]-MK-801. (r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4 -yl]-propionic Acid Sesquihydrate also selectively antagonizes AMPA-induced responses in rat cortical wedge preparations, distinguishing it from kainate-, quisqualate-, and NMDA-induced responses.

Uses

Used in Pharmaceutical Industry:
(r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4-yl]-propionic Acid Sesquihydrate is used as a selective inhibitor for [3H]-AMPA binding in rat brain membranes for the development of potential therapeutic agents targeting neurological disorders and conditions related to the AMPA receptor.
Used in Research Applications:
In the field of neuroscience research, (r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4-yl]-propionic Acid Sesquihydrate is utilized as a tool to study the role of AMPA receptors in various brain functions and to investigate the underlying mechanisms of neurological diseases associated with these receptors.
Used in Drug Development:
(r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4-yl]-propionic Acid Sesquihydrate is employed in the development of novel drugs that aim to modulate AMPA receptor activity, potentially leading to treatments for conditions such as epilepsy, Alzheimer's disease, and other neurological disorders where AMPA receptor dysfunction is implicated.