21021-55-6Relevant articles and documents
LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS
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, (2013/08/28)
The invention relates to inhibitors of sphingosine kinase enzymatic activity, compounds and pharmaceutical compositions that inhibit sphingosine kinase 1 and sphingosine kinase 2 (SphK1 and SphK2) enzymes and further relates to methods of treating diseases and disorders mediated by sphingosine 1 phosphate activity, comprising administering an effective amount of sphingosine kinase inhibitors.
Lithographic printing method
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, (2008/06/13)
A lithographic printing plate precursor comprising a support and an image-recording layer containing at least one infrared absorbing agent of a cyanine dye in which a HOMO energy level of each of substituents present on both terminal nitrogen atoms is -10.0 eV or higher. An infrared absorbing agent of a cyanide dye represented by formula (V) shown below: wherein Z 1 and Z 2 each independently represents an aromatic ring which may have a substituent or a hetero aromatic ring which may have a substituent; R 10 and R 20 each independently represents a phenyl group, a naphtyl group, an anthracenyl group, a carbazolyl group or a phenothiazinyl group each of which may have a substituent; A - represents an anion which exists in case of being necessary for neutralizing a charge and is selected from a halogen ion, a perchlorate ion, a tetrafluoroborate ion, a hexafluorophosphate ion and a sulfonate ion; and n represents 1 or 2.
Reactions in Microemulsion Media. Nucleophilic Substitution Reactions of Benzyl and p-Alkylbenzyl Chlorides
Martin, Craig A.,McCrann, Patrick M.,Ward, Mary Darlene,Angelos, George H.,Jaeger, David A.
, p. 4392 - 4396 (2007/10/02)
A kinetic and synthetic study of nucleophilic displacement reaction of bromide ion with benzyl chloride (1a) and its p-ethyl-substituted (1b) and p-n-dodecyl-substituted (1c) analogues has been performed in microemulsions prepared from combinations of a 1.23:1 (w/w) mixture (S) of cetyltrimethylammonium bromide (CTABr) and 1-butanol, a 1:5 (w/w) KBr-H2O solution (W), and hexane (O).The rates of reaction decreased differentially with increasing hexane content at a constant ratio of S:W to indicate that the interphase was the microemulsion reactive site.For microemulsion with respect to aqueous micellar and aqueous ethanol reaction media, solubilization of substrate was higher, initial reaction rates were comparable or slightly less, and overall conversions were greater.