21028-15-9Relevant articles and documents
A chiral hydrazone derived from D-glyceraldehyde: A convenient starting material for the stereoselective synthesis of α-hydrazino acids
Cativiela, Carlos,Diaz-De-Villegas, Maria D.,Gaelvez, Jose A.
, p. 1605 - 1610 (1997)
The chiral hydrazone synthesized from 2,3-di-O-benzyl-D-glyceraldehyde and benzoic acid hydrazide undergoes addition with methylmagnesium bromide in the presence of cerium trichloride in a diastereoselective manner. The major addition compound can be easi
Catalytic asymmetric reductive amination of ketones via highly enantioselective hydrogenation of the C=N double bond
Burk, Mark J.,Martinez, Jose P.,Feaster, John E.,Cosford, Nick
, p. 4399 - 4428 (2007/10/02)
We describe a convenient, chemoselective asymmetric reductive amination procedure for the conversion of ketones to chiral hydrazines and amines. The key step in the three-step process is enantioselective DuPHOS-Rh-catalyzed hydrogenation of the C=N double bond of N-acylhydrazones. Detailed optimization studies revealed the effect of solvent, temperature, and the N- acyl group on the enantioselectivity and catalytic efficiency of the reaction. The reduction products, N-acylhydrazines, were converted to hydrazines or amines through hydrolysis or treatment with samarium(II) iodide, respectively.
Amination of Chiral Enolates by Dialkyl Azodiformates. Synthesis of α-Hydrazino Acids and α-Amino Acids
Trimble, Laird A.,Vederas, John C.
, p. 6397 - 6399 (2007/10/02)
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