2103-98-2

Basic information

• Product Name: 4-(4-Chloro-phenyl)-thiazol-2-ol
• Synonyms: 4-(4-Chlorophenyl)-2-hydroxythiazole;4-(4-Chlorophenyl)-2-thiazolol;4-(4-chlorophenyl)-3H-1,3-thiazol-2-one;4-(4-chlorophenyl)-3H-thiazol-2-one;5-(4-Chlorophenyl)-1,3-thiazol-2(3H)-one;4-(4-Chlorophenyl)-1,3-thiazol-2(3H)-one;4-(4-chlorophenyl)-1,3-thiazol-2-ol
• CAS NO: 2103-98-2
• Molecular Formula: C₉H₆ClNOS
• Molecular Weight: 211.67
• Mol File: 2103-98-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 222-226 °C
• Boiling Point: 410.2 °C at 760 mmHg
• Flash Point: 201.9 °C
• Appearance: /
• Density: 1.428 g/cm³
• Vapor Pressure: 2.58E-07mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 4-(4-Chloro-phenyl)-thiazol-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chloro-phenyl)-thiazol-2-ol(2103-98-2)
• EPA Substance Registry System: 4-(4-Chloro-phenyl)-thiazol-2-ol(2103-98-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 2103-98-2(Hazardous Substances Data)

Usage

General Description

4-(4-Chloro-phenyl)-thiazol-2-ol, also known as Clioquinol, is a chemical compound with the molecular formula C9H5ClN2OS. It is a synthetic drug that has been used as an antifungal and antibacterial agent in topical medications. Clioquinol has also been investigated for its potential therapeutic effects in treating neurodegenerative diseases such as Alzheimer's and Parkinson's. However, its use has been limited due to concerns about its potential neurotoxicity and adverse effects. Despite these limitations, research on Clioquinol continues to explore its potential therapeutic applications in various medical conditions.

InChI:InChI=1/C9H6ClNOS/c10-7-3-1-6(2-4-7)8-5-13-9(12)11-8/h1-5H,(H,11,12)

Upstream product

• 19339-59-4 1-(4-chloro-phenyl)-2-thiocyanato-ethanone 
• 625-57-0 O-ethyl thiocarbamate 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 65398-74-5 Thiocarbonic acid S-[2-(4-chloro-phenyl)-2-oxo-ethyl] ester O-methyl ester 
• 333-20-0 potassium thioacyanate 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 127719-32-8 C₃₃H₃₀Cl₂N₂O₇S₂ 

Relevant articles and documents

Photo-sensitized oxy-thiocyanation of terminal alkynes/1,3-aryldienes and their one-pot conversion to 2-hydroxy 4-substituted aryl thiazoles

A regioselective visible light induced synthesis of aryl α-thiocyano ketones/thiocyano alcohols from activated terminal aryl alkynes and aryl 1,3-conjugated dienes was achieved. This mild and non-metallic oxidation is exclusively driven by benign ambient air in the presence of an organic photo-catalyst and NH4SCN. This protocol was also demonstrated at the 5 mmol scale for the synthesis of potentially therapeutic 2-hydroxy 4-substituted arylthiazoles in good yields, signifying its amenability for large-scale application.

Tetrazolinone compound and application for same

Provided is a tetrazolinone compound given by formula (1) (wherein E represents the following group E16 or the like; Y represents -O-CH2- or the like; Q represents the following group Q46 or the like; R8 represents a C1-C6 alkyl group; R3, R30, and R31 may be the same or different, and represent hydrogen atoms or the like; A represents a C6-C16 aryl group or the like, optionally having one or more atoms or groups selected from the group P1; R5 represents a C1-C3 alkyl group; and X represents an oxygen or sulfur atom), and having exceptional efficacy in controlling harmful organisms.

SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF

The present invention provides a pharmaceutical composition having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism, tumor such as breast cancer and the like, more particularly, a steroid C17,20-lyase inhibitor containing a compound represented by the formula: wherein A1 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, one of A2 and A3 is a hydrogen atom, a halogen atom, a C1-4 aliphatic hydrocarbon group optionally having substituents or an optionally esterified carboxyl group, the other of A2 and A3 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, and at least one of A1, A2 and A3 is a 3-pyridyl group optionally having substituents, or a salt thereof or a prodrug thereof.