21038-70-0

Basic information

• Product Name: 3-benzyldihydropyrimidine-2,4(1H,3H)-dione
• Synonyms: 3-benzyldihydropyrimidine-2,4(1H,3H)-dione
• CAS NO: 21038-70-0
• Molecular Weight: 204.228
• Mol File: 21038-70-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-benzyldihydropyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyldihydropyrimidine-2,4(1H,3H)-dione(21038-70-0)
• EPA Substance Registry System: 3-benzyldihydropyrimidine-2,4(1H,3H)-dione(21038-70-0)

Safety Data

• Hazardous Substances Data: 21038-70-0(Hazardous Substances Data)

Upstream product

• 1032348-78-9 N-benzyl-3-isocyanatopropanamide 
• 92033-49-3 N-benzylcarbamoyl-β-alanine ethyl ester 
• 71274-38-9 N-benzylcarbamoyl-β-alanine 

Relevant articles and documents

Synthesis of hydantoins and dihydrouracils via thermally-promoted cyclization of ureidoacetamides

The synthesis of hydantoins and dihydrouracils from ureidoacetamides has been carried out at high temperature in glycol solvents. A series of substrates were prepared and examined to determine the effect of substrate structure, N-acyl substitution (X), and solvent on the course of the reaction. A dramatic effect was observed when using ureidoacetamides (e.g., X=N-methyl-N-phenyl), which led to higher yields, faster reaction times, and lower racemization of chiral substrates. The rate of racemization of a chiral hydantoin in the presence of dibenzylamine and N-methyl aniline has also been determined. The thermal cyclization methodology has been applied to the preparation of a complex hydantoin.