210684-42-7

Basic information

• Product Name: (2R,2'S)-2-[(3'-chloro)propyl]-2-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-cyclohex-3-en-1-one
• Synonyms: (2R,2'S)-2-[(3'-chloro)propyl]-2-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-cyclohex-3-en-1-one
• CAS NO: 210684-42-7
• Molecular Weight: 313.824
• Mol File: 210684-42-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,2'S)-2-[(3'-chloro)propyl]-2-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-cyclohex-3-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,2'S)-2-[(3'-chloro)propyl]-2-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-cyclohex-3-en-1-one(210684-42-7)
• EPA Substance Registry System: (2R,2'S)-2-[(3'-chloro)propyl]-2-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-cyclohex-3-en-1-one(210684-42-7)

Safety Data

• Hazardous Substances Data: 210684-42-7(Hazardous Substances Data)

Upstream product

• 102069-84-1 (S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]benzene 
• 210684-37-0 (2'S,6R)-6-[(3'-chloro)propyl]-1-methoxy-6-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-1,4-cyclohexadiene 

Downstream Products

• 210684-53-0 (2R,3R,4R)-2-(3'-chloropropyl)-3-iodo-1-oxocyclohexane-2,4-carbolactone 
• 796866-59-6 (2E)-2-(3-chloropropyl)-4,7-dioxo-7-[(phenylmethyl)amino]-2-heptenoic acid phenylmethyl ester 
• 796866-60-9 (2E)-2-(3-chloropropyl)-4-hydroxy-7-oxo-7-[(phenylmethyl)amino]-2-heptenoic acid phenylmethyl ester 
• 796866-47-2 benzyl (2E)-2-(3-chloropropyl)-3-[(2R)-tetrahydro-5-oxofuran-2-yl]-2-propenoate 

Relevant articles and documents

Novel fragmentation reaction of 2-alkyl- and 2,4-dialkyl-3-iodo-1- oxocyclohexan-2,4-carbolactones

2-Alkyl- and 2,4-dialkyl-3-iodo-1-oxocyclohexan-2,4-carbolactones undergo lithium hydroxide- and lithium alkoxide-induced fragmentation reactions to provide butenolides, γ-hydroxycyclohexenones, and/or γ- butyrolactones. In general, product distribution is governed by two factors: (1) the nature of nucleophiles and (2) the steric bulkiness of the substituents at C-2 and C-4 of the cyclohexanones. Lithium hydroxide-induced fragmentation provides butenolides and γ-hydroxycyclohexenones. In contrast, lithium alkoxide-promoted fragmentation results in predominantly 5-substituted γ-butyrolactones along with a small amount of butenolides in limited cases. Fragmentation products induced by lithium hydroxide are largely influenced by the steric bulkiness of the substituents at C-2 and C-4 of the cyclohexanone ring. The bulky substituents render the exclusive formation of butenolides.