21075-85-4

Basic information

• Product Name: N'-benzylidene-N-methylhydrazinecarboxylic acid tert-butyl ester
• Synonyms: N'-benzylidene-N-methylhydrazinecarboxylic acid tert-butyl ester
• CAS NO: 21075-85-4
• Molecular Weight: 234.298
• Mol File: 21075-85-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N'-benzylidene-N-methylhydrazinecarboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N'-benzylidene-N-methylhydrazinecarboxylic acid tert-butyl ester(21075-85-4)
• EPA Substance Registry System: N'-benzylidene-N-methylhydrazinecarboxylic acid tert-butyl ester(21075-85-4)

Safety Data

• Hazardous Substances Data: 21075-85-4(Hazardous Substances Data)

Upstream product

• 24469-50-9 t-butyl 3-benzylidenecarbazate 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 29518-83-0 S-Methyl-monothiokohlensaeure-tert.-butylester 
• 21075-83-2 1-methyl-1-tert-butoxycarbonylhydrazine 
• 100-52-7 benzaldehyde 

Downstream Products

• 1447819-18-2 C₁₅H₂₂N₂O₄ 
• 1447819-09-1 C₂₅H₃₄N₄O₅ 
• 1447819-10-4 C₂₄H₃₂N₄O₅ 
• 1447819-05-7 C₁₉H₂₂N₄O₂ 
• 21076-95-9 2-Benzyl-1,4-dimethyl-thiosemicarbazid 
• 197635-14-6 C₂₃H₂₈N₂O₆ 
• 347392-00-1 2-Benzyl-1-tert.-butoxycarbonyl-1-methyl-hydrazin 

Relevant articles and documents

Stereodynamics of nitrogen chiral centers in aza-β3- cyclodipeptides

The present work is devoted to the synthesis, conformational analysis, and stereodynamic study of aza-β3-cyclodipeptides. This pseudopeptidic ring shows E/Z hydrazide bond isomerism, eight-membered ring conformation, and chirotopic nitrogen atoms, all of which are elements that are prone to modulate the ring shape. The (E,E) twist boat conformation observed in the solid state by X-ray diffraction is also the ground conformation in solution, and emerges as the lowest in energy when using quantum chemical calculations. The relative configuration associated with ring chirality and with the two nitrogen chiral centers is governed by steric crowding and adopts the (P)SNSN/(M)RNRN combination which projects side chains in equatorial position. The nitrogen pyramidal inversion (NPI) at the two chiral centers is correlated with the ring reversal. The process is significantly hindered as was shown by VT-NMR experiments run in C2D2Cl4, which did not make it possible to determine the barrier to inversion. Finally, these findings make it conceivable to resolve enantiomers of aza-β3-cyclodipeptides by modulating the backbone decoration appropriately.

Azadepsipeptides: Synthesis and evaluation of a novel class of peptidomimetics

A general route to azadepsipeptides, a new class of pseudopeptides, has been established. The methodology was applied to the synthesis of a bis-aza analogue of the antiparasitic cyclooctadepsipeptide PF1022A. Comparison of the X-ray crystal structures of natural PF1022A (8) and the chimeric aza analogue 9 revealed that the introduction of nitrogen in the backbone of PF1022A results in almost complete conservation of the 3D structure with only minor deviations at the new nitrogen positions.