21081-94-7

Basic information

• Product Name: Phosphinothioic acid, diphenyl-, S-(4-chlorophenyl) ester
• CAS NO: 21081-94-7
• Molecular Formula: C18H14ClOPS
• Molecular Weight: 344.801
• Mol File: 21081-94-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Phosphinothioic acid, diphenyl-, S-(4-chlorophenyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinothioic acid, diphenyl-, S-(4-chlorophenyl) ester(21081-94-7)
• EPA Substance Registry System: Phosphinothioic acid, diphenyl-, S-(4-chlorophenyl) ester(21081-94-7)

Safety Data

• Hazardous Substances Data: 21081-94-7(Hazardous Substances Data)

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 829-85-6 diphenylphosphane 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 719-80-2 Ethyl diphenylphosphinite 
• 42839-20-3 1-((4-chlorophenyl)thio)pyrrolidine-2,5-dione 
• 4559-70-0 Diphenylphosphine oxide 
• 108-86-1 bromobenzene 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 75980-60-8 (2,4,6-trimethylbenzoyl)diphenylphosphine oxide 
• 100-03-8 4-chlorobenzenesulfinic acid 
• 5138-90-9 sodium 4-chlorobenzenesulfonate 
• 1079-66-9 chloro-diphenylphosphine 
• 1499-21-4 Diphenylphosphinic chloride 

Downstream Products

• 98-66-8 4-chloro-benzenesulfonic acid 
• 1707-03-5 diphenyl-phosphinic acid 

Relevant articles and documents

Tf2O/DMSO-Promoted P-O and P-S Bond Formation: A Scalable Synthesis of Multifarious Organophosphinates and Thiophosphates

A Tf2O/DMSO-based system for the dehydrogenative coupling of a wide range of alcohols, phenols, thiols, and thiophenols with diverse phosphorus reagents has been developed. This metal- and strong-oxidant-free strategy provides a facile approach to a great variety of organophosphinates and thiophosphates. The simple reaction system, good functional-group tolerance, and broad substrate scope enable the application of this method to the modification of natural products and the direct synthesis of bioactive molecules and flame retardants.

An Alternative Metal-Free Aerobic Oxidative Cross-Dehydrogenative Coupling of Sulfonyl Hydrazides with Secondary Phosphine Oxides

An alternative metal-free, efficient and practical approach for the preparation of phosphinothioates is established via the aerobic oxidative cross-dehydrogenative coupling (CDC) of sulfonyl hydrazides with secondary phosphine oxides catalyzed by tetrabutylammonium iodide (TBAI) in the presence of atmospheric oxygen. The strategy provides an array of diverse phosphinothioates in good to excellent yields. Furthermore, two representative bioactive molecules are synthesized on up to gram scale by utilizing this method.

Preparation method of compound containing P-O bond or P-S bond

The invention discloses a preparation method of a compound containing a P-O bond or a P-S bond. The method comprises the following steps: a compound containing hydroxyl or sulfydryl and a phosphorus reagent are taken as initial raw materials; then, the initial raw materials are put into an inert gas atmosphere; and under the action of trifluoromethanesulfonic anhydride (Tf2O) and dimethyl sulfoxide (DMSO), the compound containing hydroxyl or sulfydryl, the phosphorus reagent, the trifluoromethanesulfonic anhydride and the dimethyl sulfoxide in a molar ratio of (1-5): (1-2.5): (2-3): 2 react inan organic solvent at the reaction temperature of 25-100 DEG C for 6-20 hours to obtain the compound with the structural general formula (I). The reagents used in the method are low in toxicity and environmentally friendly, and use of precious metal catalysts high in price and toxicity is avoided. The reagents trifluoromethanesulfonic anhydride (Tf2O) and dimethyl sulfoxide (DMSO) used in the method are low in toxicity and very low in cost, so that the method is green, environment-friendly, high in economy and suitable for large-scale production.