210825-01-7Relevant articles and documents
Syntheses of the marine ascidian purine aplidiamine and its 9-β-D- ribofuranoside
Itaya, Taisuke,Hozumi, Yoshitaka,Kanai, Tae,Ohta, Tomihisa
, p. 4695 - 4696 (1998)
The title nucleoside 9 was synthesized by alkylation of 8-oxoadenosine (7) with 4-benzyloxy-3,5-dibromobenzyl bromide, followed by Dimroth rearrangement and acid hydrolysis. 2'-Deoxy version of this reaction sequence accomplished the first synthesis of aplidiamine (6).