21083-30-7 Usage
General Description
Phenylthiohydantoin alpha-aminoisobutyric acid, also known as PTPIAA, is a chemical compound that consists of a phenylthiohydantoin group and an alpha-aminoisobutyric acid group. It is often used in peptide synthesis as a protecting group for the carboxylic acid function, allowing for selective deprotection and subsequent coupling reactions. PTPIAA is known for its ability to selectively protect the carboxyl group in the presence of other functional groups, making it a valuable tool in organic chemistry. It is widely used to synthesize peptides and to study their structure and function in biological systems. PTPIAA has also been investigated for its potential as a drug delivery vehicle for targeted therapy in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 21083-30-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,0,8 and 3 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 21083-30:
(7*2)+(6*1)+(5*0)+(4*8)+(3*3)+(2*3)+(1*0)=67
67 % 10 = 7
So 21083-30-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2OS/c1-11(2)9(14)13(10(15)12-11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,12,15)
21083-30-7Relevant articles and documents
Cycloaddition Reactions of Heterocumulenes, XXVIII. - A 1,6-Dipole Stabilized by No-Bond Resonance. - Molecular Structure and Reactivity
Schaumann, Ernst,Kausch, Erwin,Klaska, Karl-Heinz,Klaska, Rolf,Eck, Joachim
, p. 405 - 410 (2007/10/02)
The X-ray structural investigation of the 1,6-dipole 1 reveals an intramolecular S-N contact of 236 pm, which indicates stabilization by no-bond resonance.In reactions with the heterocumulenes 2-5, the thiazoline ring of 1 is opened to give the heterocycles 7a-f, 8e.The reaction of bis(trimethylsilyl)thioketene (6) takes a deviating pathway: the primary adduct 15 gives a sigmatropic 1,3 shift of the dimethylamino group to yield product 16b.This constitution is derived from an X-ray structural study of the degradation product 17.
