210886-12-7

Basic information

• Product Name: L-Tyrosine N-[6(S)-benzyl-1-methyl-5,8,11-trioxo-1,2,7,10-tetraazacyclotridecan-12(R)-yl]amide
• CAS NO: 210886-12-7
• Molecular Formula: C₂₆H₃₄N₆O₅
• Molecular Weight: 510.59808
• Mol File: 210886-12-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Tyrosine N-[6(S)-benzyl-1-methyl-5,8,11-trioxo-1,2,7,10-tetraazacyclotridecan-12(R)-yl]amide(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine N-[6(S)-benzyl-1-methyl-5,8,11-trioxo-1,2,7,10-tetraazacyclotridecan-12(R)-yl]amide(210886-12-7)
• EPA Substance Registry System: L-Tyrosine N-[6(S)-benzyl-1-methyl-5,8,11-trioxo-1,2,7,10-tetraazacyclotridecan-12(R)-yl]amide(210886-12-7)

Safety Data

• Hazardous Substances Data: 210886-12-7(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 5893-05-0 Trt-Gly 
• 47375-34-8 Boc-Tyr(t-Bu)-OH 
• 88224-00-4 L-phenylalanine allyl ester p-toluenesulfonic acid salt 
• 487027-90-7 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-nitro-benzenesulfonylamino)-propionic acid 
• 210818-42-1 ((R)-2-[(S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionylamino]-3-{[2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyl]-methyl-amino}-propionylamino)-acetic acid tert-butyl ester 
• 210818-41-0 ((R)-2-Benzyloxycarbonylamino-3-{[2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyl]-methyl-amino}-propionylamino)-acetic acid tert-butyl ester 
• 210818-40-9 Boc-L-Phe-NH(CH₂)2NHMe 
• 142955-51-9 N-butoxycarbonyl-L-phenylalanine anhydride 
• 86827-18-1 N-benzyloxycarbonyl-O-benzyl-L-tyrosine 
• 210818-43-2 [(S)-1-((6S,12R)-6-Benzyl-1-methyl-5,8,11-trioxo-1,4,7,10-tetraaza-cyclotridec-12-ylcarbamoyl)-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid benzyl ester 

Relevant articles and documents

Solid-phase synthesis of amine-bridged cyclic enkephalin analogues via on-resin cyclization utilizing the Fukuyama-Mitsunobu reaction

An efficient solid-phase synthetic route is described for the preparation of 13-membered amine-bridged cyclic enkephalin analogues (ABEs) 1a and 1c-1j (Figure 1) resulting from a sulfonamide-containing peptide whose backbone is bound to a resin. The Fukuyama-Mitsunobu reaction of the 2-nitrobenzenesulfonyl-protected amine bound to the solid support with protected aminoethanol in the presence of triphenylphosphine and diisopropyl azodicarboxylate (DIAD) is utilized to prepare a resin-bound sulfonamide-protected secondary amine. After peptide cyclization, this protected amine functionality becomes the "amine bridge" of the target molecule. In addition, the reagent DIAD was found to be a superior reagent compared to diethyl azodicarboxylate (DEAD) in the solid-phase Fukuyama-Mitsunobu reaction.