21102-95-4

Basic information

• Product Name: BMY 7378 DIHYDROCHLORIDE
• Synonyms: 8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:2);8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride BMY7378;BMY 7378, >=98%;BMY 7378 2hydrochloride;8-(2-(4-(2-Methoxyphenyl);-8-azaspiro[4.5]decane-7,9-dione dihydrochloride;BMY7378 HCl;1-cyclopentanediacetimide,n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-d
• CAS NO: 21102-95-4
• Molecular Formula: C22H33Cl2N3O3
• Molecular Weight: 458.42
• Product Categories: Inhibitors;Serotonin receptor
• Mol File: 21102-95-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 585.6°C at 760 mmHg
• Flash Point: 307.9°C
• Appearance: white/solid
• Vapor Pressure: 1.07E-13mmHg at 25°C
• Storage Temp.: Store at RT
• Solubility: H2O: soluble
• CAS DataBase Reference: BMY 7378 DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BMY 7378 DIHYDROCHLORIDE(21102-95-4)
• EPA Substance Registry System: BMY 7378 DIHYDROCHLORIDE(21102-95-4)

Safety Data

• WGK Germany: 3
• RTECS: GY3996000
• Hazardous Substances Data: 21102-95-4(Hazardous Substances Data)

Usage

Uses

BMY 7378 dihydrochloride is a SR-1A agonist and a selective α1D-AR antagonist.

Biological Activity

5-HT 1A partial agonist and high affinity α 1D adrenoceptor antagonist (K i values are 2, 800 and 600 nM at cloned rat α 1D , rat α 1A and hamster α 1B receptors respectively). Also available as part of the α 1 -Adrenoceptor Tocriset? .

Biochem/physiol Actions

BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist.

references

1. yocca fd, hyslop dk, smith dw et al. bmy 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-ht1a receptor in rat and guinea pig hippocampal membranes. eur j pharmacol. 1987 jun 4;137(2-3):293-4.2. zemlan fp, zieleniewski-murphy a, maureen murphy r et al bmy 7378: partial agonist at spinal cord 5-ht(1a) receptors. neurochem int. 1990;16(4):515-22.3. goetz as, king hk, ward sd et al. bmy 7378 is a selective antagonist of the d subtype of alpha 1-adrenoceptors. eur j pharmacol. 1995 jan 16;272(2-3):r5-6.4. cleary l, murad k, bexis s et al. the alpha (1d)-adrenoceptor antagonist bmy 7378 is also an alpha (2c)-adrenoceptor antagonist. auton autacoid pharmacol. 2005 oct;25(4):135-41.5. sharp t, backus li, hjorth s et al. further investigation of the in vivo pharmacological properties of the putative 5-ht1a antagonist, bmy 7378. eur j pharmacol. 1990 feb 13;176(3):331-40.

InChI:InChI=1/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H