211228-56-7

Basic information

• Product Name: 2-(3,4-bis-benzyloxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one
• Synonyms: 2-(3,4-bis-benzyloxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one
• CAS NO: 211228-56-7
• Molecular Weight: 510.543
• Mol File: 211228-56-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3,4-bis-benzyloxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-bis-benzyloxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one(211228-56-7)
• EPA Substance Registry System: 2-(3,4-bis-benzyloxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one(211228-56-7)

Safety Data

• Hazardous Substances Data: 211228-56-7(Hazardous Substances Data)

Upstream product

• 1486-61-9 3',4'-bis(benzyloxy)-5,7-dihydroxy-3-methoxyflavone 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 55317-02-7 2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone 
• 58605-10-0 methyl 3,5-bis(benzyloxy)benzoate 
• 1570-05-4 3,4-bis(benzyloxy)benzoic acid 
• 1592-48-9 3,4-bis-benzyloxy-benzoic acid-anhydride 

Downstream Products

• 2068-02-2 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxychromen-4-one 

Relevant articles and documents

Synthesis and antiviral activity of 7-O-(ω-substituted)-alkyl-3-O- methylquercetin derivatives

3',4'-Di-O-benzyl-3-O-methylquercetin (2), the precursor in the synthesis of an important antivirally active flavone 3-O-methylquercetin (1), was regioselectively alkylated at the 7-OH position by a series of 1,ω- dihaloalkanes and ω-bromoalkanols. Dimerization of the flavone had to be avoided by applying strict reaction conditions. Subsequent debenzylation was carried out by catalytic transfer hydrogenolysis, affording quantitatively the 7-O-(ω-haloalkyl)-3-O-methylquercetin (11-14) and 7-O-(ω- hydroxyalkyl)-3-O-methylquercetin derivatives (15, 16). All compounds were tested for their antiviral activity against poliomyelitis- and HIV-viruses.