211308-81-5

Basic information

• Product Name: 2-AMINO-5-CHLORO-3-IODOPYRIDINE
• Synonyms: 2-AMINO-5-CHLORO-3-IODOPYRIDINE;5-CHLORO-3-IODO-PYRIDIN-2-YLAMINE;2-AMINO-5-CHLORO-4-IODOPYRIDINE;5-chloro-3-iodo-2-pyridinamine;5-Chloro-3-iodopyridin-2-amine;2-PyridinaMine, 5-chloro-3-iodo-
• CAS NO: 211308-81-5
• Molecular Formula: C₅H₄ClIN₂
• Molecular Weight: 254.46
• Mol File: 211308-81-5.mol
• Article Data: 27

Chemical Properties

• Melting Point: 137-138°C
• Boiling Point: 306.902 °C at 760 mmHg
• Flash Point: 139.41 °C
• Appearance: Yellow dust
• Density: 2.139 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.708
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.27±0.49(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-AMINO-5-CHLORO-3-IODOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-CHLORO-3-IODOPYRIDINE(211308-81-5)
• EPA Substance Registry System: 2-AMINO-5-CHLORO-3-IODOPYRIDINE(211308-81-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 211308-81-5(Hazardous Substances Data)

Usage

Description

2-AMINO-5-CHLORO-3-IODOPYRIDINE is a synthetic intermediate with potential applications in the pharmaceutical industry due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-CHLORO-3-IODOPYRIDINE is used as a synthetic intermediate for the rational design of highly selective spleen tyrosine kinase inhibitors. These inhibitors can potentially be used in the development of treatments for various diseases and conditions.
Used in Antibacterial and Antifungal Applications:
2-AMINO-5-CHLORO-3-IODOPYRIDINE is also used in the synthesis of azaindole derivatives, which exhibit antibacterial and antifungal activities. These derivatives can be further developed into new drugs or agents to combat bacterial and fungal infections.

InChI:InChI=1/C5H4ClIN2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 

Downstream Products

• 351227-39-9 Methyl 5-Chloro-2-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-propanoate 
• 1258504-39-0 N-(2-(5-chloro-2-(triethylsilyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl)-5-(2,5-difluorobenzyl)isoxazole-3-carboxamide 
• 866546-07-8 5-chloro-1H-pyrrolo[2,3-b]pyridine 
• 1001014-88-5 C₇H₇ClN₂O 
• 937054-22-3 ethyl 2-(1-{2-[(5S,7R)-3-chloro-5-(2,3-dimethoxyphenyl)-5H,7H-pyrido[2,3-e]-pyrrolo[2,1-c][1,4]oxazepin-7-yl]acetyl}-4-piperidinyl)acetate 
• 937054-23-4 ethyl 2-(1-{2-[(5R,7S)-3-chloro-5-(2,3-dimethoxyphenyl)-5H,7H-pyrido[2,3-e]-pyrrolo[2,1-c][1,4]oxazepin-7-yl]acetyl}-4-piperidinyl)acetate 
• 937054-24-5 2-(1-{2-[(5S,7R)-3-chloro-5-(2,3-dimethoxyphenyl)-5H,7H-pyrido[2,3-e]-pyrrolo[2,1-c][1,4]oxazepin-7-yl]acetyl}-4-piperidinyl)acetic acid 
• 937054-21-2 ethyl 2-(1-{2-[3-chloro-5-(2,3-dimethoxyphenyl)-5H,7H-pyrido[2,3-e]-pyrrolo[2,1-c][1,4]oxazepin-7-yl]acetyl}-4-piperidinyl)acetate 
• 937057-57-3 Methyl (E)-3-(1-[5-chloro-3-(2,3-dimethoxybenzoyl)-2-pyridinyl]-1H-pyrrol-2-yl)-propenoate 
• 937054-20-1 2-[3-Chloro-5-(2,3-dimethoxyphenyl)-5H,7H-pyrido[2,3-e]-pyrrolo[2,1-c][1,4]oxazepin-7-yl]acetic acid 
• 937054-19-8 Methyl 2-[3-chloro-5-(2,3-dimethoxyphenyl)-5H,7H-pyrido[2,3-e]-pyrrolo[2,1-c][1,4]oxazepin-7-yl]acetate 
• 800401-18-7 2-(S)-[(5-chloro-1H-pyrrolo[2,3-b]pyridine-2-carbonyl)amino]-3-(4-fluorophenyl)propionic acid 

Relevant articles and documents

2 - Amino - 3 - iodo - 5 - chloro pyridine synthesis method

The invention relates to a method for synthesizing 2-amino-3-iodo-5-chloropyridine. The method comprises the steps of enabling 2-amino-5-chloropyridine and N-iodo succinimide, which serve as raw materials and are in the mass ratio of 1: (1.5-4.5), to react at the temperature of 10-102 DEG C in a proper solvent, so as to produce 2-amino-3-iodo-5-chloropyridine, and purifying, thereby obtaining a pure product 2-amino-3-iodo-5-chloropyridine. According to the method, the raw materials are relatively easily obtained and are reasonable in price; meanwhile, during preparation reaction, no heavy metal and corrosive gas are used, the reaction is mild, no special requirements on reaction equipment are required, and ordinary corrosion-resistant equipment can be applied to production; in addition, reaction conditions of the method are moderate.

HETEROARYLS AND USES THEREOF

The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

The acid-catalysed synthesis of 7-azaindoles from 3-alkynyl-2- aminopyridines and their antimicrobial activity

The synthesis of 7-azaindoles from 3-alkynyl-2-aminopyridines using acidic conditions, namely, a mixture of trifluoroacetic acid (TFA) and trifluoroacetic anhydride (TFAA), is described. This methodology resulted in the synthesis of fifteen 7-azaindoles, with most containing substituents at the 2- and 5-positions. The majority of these were tested for antimicrobial activity against a range of bacteria and yeasts. The 7-azaindoles displayed the best activity against the yeasts, particularly against Cryptococcus neoformans, where activities as low as 3.9 μg ml-1 were observed.