211318-52-4

Basic information

• Product Name: ethyl 2-diazo-3-(4-methylphenyl)-3-hydroxypropanoate
• Synonyms: ethyl 2-diazo-3-(4-methylphenyl)-3-hydroxypropanoate
• CAS NO: 211318-52-4
• Molecular Weight: 234.255
• Mol File: 211318-52-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: ethyl 2-diazo-3-(4-methylphenyl)-3-hydroxypropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-diazo-3-(4-methylphenyl)-3-hydroxypropanoate(211318-52-4)
• EPA Substance Registry System: ethyl 2-diazo-3-(4-methylphenyl)-3-hydroxypropanoate(211318-52-4)

Safety Data

• Hazardous Substances Data: 211318-52-4(Hazardous Substances Data)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 27835-00-3 ethyl (4-methylbenzoyl)acetate 
• 797756-83-3 3-hydroxy-2-(4-methylphenyl)acrylic acid ethyl ester 
• 1591911-96-4 C₂₃H₂₂FeN₂O₄ 

Relevant articles and documents

Catalytic aldol-type reaction of aldehydes with ethyl diazoacetate using quarternary ammonium hydroxide as the base

The direct aldol-type condensation of aldehydes with ethyl diazoacetate (EDA) promoted by an organic base and non-metallic catalyst such as tetrabutylammonium hydroxide (TBAOH) gave β-hydroxy-α-diazocarbonyl compounds with moderate to excellent yields. Furthermore, the reactivity and scope of various phase-transfer catalysts as well as electronically divergent aldehydes are discussed.

Pyrrolidine-catalyzed condensation of ethyl diazoacetate to aldehydes in water

A simple and convenient protocol for the synthesis of-diazo carbonyl compounds from the condensation of ethyl diazoacetate to aldehydes in water was developed using pyrrolidine as a catalyst. Copyright

Deep eutectic solvent (DES) as dual solvent/catalyst for synthesis of α-diazocarbonyl compounds using aldol-type coupling

Deep eutectic solvent (DES) was employed as dual solvent/catalyst in the green synthesis of α-diazocarbonyl compounds using aldol-type coupling. α-Diazocarbonyl compounds are important synthetic intermediates with useful application for synthesis of amino alcohols and acids and many natural products. Moreover, the method is environmentally friendly because of avoidance of toxic solvents or hazardous catalysts.

Continuous flow synthesis of toxic ethyl diazoacetate for utilization in an integrated microfluidic system

An integrated microfluidic system for multiple reactions and separations of hazardous ethyl diazoacetate is presented. The integrated techniques include: a droplet technique for liquid-liquid and/or gas-liquid separation and in situ generation of the toxic reagent, a dual channel membrane technique based on a cheap polymeric microseparator for liquid-liquid separation, and a capillary microreactor for carrying out cascade reactions in a sequential and continuous manner.