21134-02-1

Basic information

• Product Name: 3-(4-Chloro-phenyl)-3-hydroxy-pentanoic acid ethyl ester
• Synonyms: 3-(4-Chloro-phenyl)-3-hydroxy-pentanoic acid ethyl ester
• CAS NO: 21134-02-1
• Molecular Weight: 256.729
• Mol File: 21134-02-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(4-Chloro-phenyl)-3-hydroxy-pentanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Chloro-phenyl)-3-hydroxy-pentanoic acid ethyl ester(21134-02-1)
• EPA Substance Registry System: 3-(4-Chloro-phenyl)-3-hydroxy-pentanoic acid ethyl ester(21134-02-1)

Safety Data

• Hazardous Substances Data: 21134-02-1(Hazardous Substances Data)

Upstream product

• 6285-05-8 4'-chloropropiophenone 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 21133-92-6 4-(4-Chloro-phenyl)-2-methyl-hexane-2,4-diol 
• 21133-84-6 3-(4-Chloro-phenyl)-5-ethyl-heptane-3,5-diol 

Relevant articles and documents

Mevalonic acid analogs as inhibitors of cholesterol biosynthesis

A series of 20 mevalonic acid analogs were synthesized and tested for their ability to inhibit cholesterol biosynthesis from [2-14C]-mevalonate in rat liver homogenates. Removal of the 5-hydroxyl group from mevalonic acid produced an active inhibitor, 3-hydroxy-3-methylpentanoic acid. Removal of the 3-hydroxyl group, addition of an aromatic group in the 3-position, or insertion of a double bond reduced inhibitory activity. Compounds with an aromatic group or halide on the 5-position were active inhibitors. The most active inhibitor was 5-phenylpentanoic acid, with 50% inhibition at 0.064 mM.