21147-23-9

Basic information

• Product Name: 2,4-Dimethoxy-4hydroxybenzophenone
• Synonyms: 2-(4-Hydroxybenzoyl)benzoic acid methyl ester
• CAS NO: 21147-23-9
• Molecular Formula: C₁₅H₁₂O₄
• Molecular Weight: 256.25
• Mol File: 21147-23-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 415.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.256±0.06 g/cm3(Predicted)
• PKA: 7.60±0.15(Predicted)
• CAS DataBase Reference: 2,4-Dimethoxy-4hydroxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethoxy-4hydroxybenzophenone(21147-23-9)
• EPA Substance Registry System: 2,4-Dimethoxy-4hydroxybenzophenone(21147-23-9)

Safety Data

• Hazardous Substances Data: 21147-23-9(Hazardous Substances Data)

Usage

General Description

2,4-Dimethoxy-4hydroxybenzophenone, also known as benzophenone-6, is a chemical compound commonly used in sunscreen and other personal care products as a UV filter. It works by absorbing and dissipating UV radiation, helping to protect the skin from sun damage and premature aging. 2,4-Dimethoxy-4hydroxybenzophenone is a derivative of benzophenone, a widely used ingredient in sunscreens known for its ability to protect against both UVA and UVB rays. Despite its effectiveness in sun protection, there are some concerns about the potential health risks associated with benzophenone-based compounds, including 2,4-Dimethoxy-4hydroxybenzophenone, and their effects on the environment. Some studies indicate that benzophenone derivatives may be hormonally disruptive and have the potential to bioaccumulate in aquatic ecosystems, raising questions about their long-term impacts. Overall, while 2,4-Dimethoxy-4hydroxybenzophenone is an effective UV filter, its potential health and environmental risks warrant further research and regulatory scrutiny.

Upstream product

• 186581-53-3 diazomethane 
• 85-57-4 2-(4-hydroxy-benzoyl)-benzoic acid 
• 67-56-1 methanol 
• 33577-99-0 2-ethynyl-benzoic acid methyl ester 
• 108-95-2 phenol 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1151-15-1 2-(4-methoxybenzoyl)benzoic acid 
• 85-44-9 phthalic anhydride 
• 77-09-8 phenolphthalein 
• 100-66-3 methoxybenzene 

Downstream Products

• 696619-41-7 2-[4-(3-benzyloxy-propoxy)-benzoyl]-benzoic acid methyl ester 
• 696619-60-0 2-[4-(3-hydroxy-propoxy)-benzoyl]-benzoic acid tert-butyl ester 
• 696619-51-9 2-[4-(3-benzyloxy-propoxy)-benzoyl]-benzoic acid tert-butyl ester 
• 696619-69-9 2-(4-{3-[1-tert-butoxycarbonyl-2-(4-hydroxy-3,5-diiodo-phenyl)-ethylcarbamoyloxy]-propoxy}-benzoyl)-benzoic acid tert-butyl ester 
• 54063-52-4 2-methoxycarbonyl-4'-(2-piperidinoethyloxy)benzophenone 
• 1613030-83-3 C₁₈H₁₄O₄ 
• 1613030-86-6 C₃₂H₂₂N₂O₂ 
• 1613030-84-4 C₁₇H₁₂O₄ 
• 878022-65-2 2-benzyl-3-hydroxy-3-[4-(2-trimethylsilanylethoxymethoxy)phenyl]-2,3-dihydroisoindol-1-one 
• 878022-67-4 2-benzyl-3-chloro-3-[4-(2-trimethylsilanylethoxymethoxy)phenyl]-2,3-dihydro-isoindol-1-one 
• 878022-62-9 2-[4-(2-trimethylsilanylethoxymethoxy)benzoyl]benzoic acid 
• 849723-45-1 3-chloro-3-[4-(2-trimethylsilanylethoxymethoxy)phenyl]-3H-isobenzofuran-1-one 
• 878022-59-4 2-[4-(2-trimethylsilanylethoxymethoxy)benzoyl]benzoic acid methyl ester 
• 33230-95-4 2-(4-hydroxy-benzyl)-benzyl alcohol 

Relevant articles and documents

Visible Light Copper Photoredox-Catalyzed Aerobic Oxidative Coupling of Phenols and Terminal Alkynes: Regioselective Synthesis of Functionalized Ketones via C C Triple Bond Cleavage

Direct oxidative coupling of phenols and terminal alkynes was achieved at room temperature by a visible-light-mediated copper-catalyzed photoredox process. This method allows regioselective synthesis of hydroxyl-functionalized aryl and alkyl ketones from simple phenols and phenylacetylene via C C triple bond cleavage. 47 examples were presented. From a synthetic perspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical drugs, such as pitofenone and fenofibrate.

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold

From a set of weakly potent lead compounds, using in silico screening and small library synthesis, a series of 2-alkyl-3-aryl-3-alkoxyisoindolinones has been identified as inhibitors of the MDM2-p53 interaction. Two of the most potent compounds, 2-benzyl-3-(4-chlorophenyl)-3-(3-hydroxypropoxy)-2,3- dihydroisoindol-1-one (76; IC50 = 15.9 ± 0.8 μM) and 3-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethoxybenzyloxy)-2-propyl-2, 3-dihydroisoindol-1-one (79; IC50 = 5.3 ± 0.9 μM), induced p53-dependent gene transcription, in a dose-dependent manner, in the MDM2 amplified, SJSA human sarcoma cell line.