211760-13-3

Basic information

• Product Name: 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-[3-[3-[(tetrahydropyran-2-yl)oxy]phenyl]ureido]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one
• CAS NO: 211760-13-3
• Molecular Weight: 600.715
• Mol File: 211760-13-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-[3-[3-[(tetrahydropyran-2-yl)oxy]phenyl]ureido]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-[3-[3-[(tetrahydropyran-2-yl)oxy]phenyl]ureido]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one(211760-13-3)
• EPA Substance Registry System: 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-[3-[3-[(tetrahydropyran-2-yl)oxy]phenyl]ureido]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one(211760-13-3)

Safety Data

• Hazardous Substances Data: 211760-13-3(Hazardous Substances Data)

Upstream product

• 1877-77-6 3-aminobenzenemethanol 
• 213664-68-7 3-azido-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 147985-36-2 m-tetrahydropyran-2-yloxyaminobenzene 
• 118684-31-4 tert-butyl N-[3-(hydroxymethyl)phenyl]carbamate 
• 118684-32-5 [3-[N-(tert-butoxycarbonyl)amino]phenyl]methyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 239097-32-6 3-amino-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 

Relevant articles and documents

1,3-Disubstituted benzazepines as neuropeptide Y Y1 receptor antagonists

A novel class of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Through a blind screening we found the compound 1-N-(3-(N' -(tert-butoxycarbonyl)amino)benzyl)-7-methoxy-3-(3)-methylureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (9: IC50 =1.6 μM). Chemical modifications of 9 gave a potent NPY Y1 antagonist 3-(N-(4-hydroxyphenyl)-N0 -methylguanidino)-1-N-(3-(N'-(tert- butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (14c: IC50 =43 nM), which had no affnity for NPY Y2 and Y5 receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.