21203-86-1

Basic information

• Product Name: 2-PHENYL-PYRIDIN-4-YLAMINE
• Synonyms: 4-AMINO-2-PHENYLPYRIDINE;2-PHENYL-PYRIDIN-4-YLAMINE;2-Phenylpyridin-4-aMine;Pyridine, 4-amino-2-phenyl-
• CAS NO: 21203-86-1
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.21
• Product Categories: API intermediates
• Mol File: 21203-86-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 384.2°Cat760mmHg
• Flash Point: 214.4°C
• Appearance: /
• Density: 1.133g/cm³
• Vapor Pressure: 4.16E-06mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-PHENYL-PYRIDIN-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-PYRIDIN-4-YLAMINE(21203-86-1)
• EPA Substance Registry System: 2-PHENYL-PYRIDIN-4-YLAMINE(21203-86-1)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 21203-86-1(Hazardous Substances Data)

Usage

General Description

2-Phenyl-pyridin-4-ylamine is a chemical compound with the molecular formula C11H10N2. It is an arylamine derivative with a pyridine ring, and its structure contains a phenyl group attached to the pyridine ring. 2-PHENYL-PYRIDIN-4-YLAMINE has potential applications in pharmaceutical research and drug discovery due to its structural similarity to various biologically active molecules. It may serve as a building block in the synthesis of new pharmaceuticals or as a ligand in the development of new drugs. Additionally, it may have potential industrial uses in the synthesis of organic compounds or materials. However, it is important to handle this chemical with care due to potential hazards and toxicological properties.

InChI:InChI=1/C11H10N2/c12-10-6-7-13-11(8-10)9-4-2-1-3-5-9/h1-8H,(H2,12,13)

Upstream product

• 7598-35-8 2-bromo-4-aminopyridine 
• 98-80-6 phenylboronic acid 
• 14432-12-3 4-Amino-2-chloropyridine 
• 108-90-7 chlorobenzene 
• 19798-80-2 2-Amino-4-chloropyridine 

Downstream Products

• 848580-35-8 5-iodo-2-phenyl-pyridin-4-ylamine 
• 57311-18-9 4-chloro-2-phenyl-pyridine 
• 33399-34-7 4-phenoxy-2-phenylpyridine 

Relevant articles and documents

N-pyridine-4-yl-benzamide Cdc37 inhibitor as well as derivative and application thereof

The invention discloses an N-pyridine-4-yl-benzamide Cdc37 inhibitor with a structure as shown in a general formula (I) as well as a derivative and application thereof. The compound disclosed by the invention can inhibit Cdc37 protein and downstream custo

UREA DERIVATIVES AS CB1 ALLOSTERIC MODULATORS

Heteroaryl and aliphatic analogs of diarylurea-based cannabinoid 1 receptor (CB1 R) allosteric modulators of formula (I) are described. Exemplary analogs can provide improved potencies and pharmacokinetic properties. Methods of using the analogs to treat

Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators

We previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB1) allosteric modulators, which were effective in attenuating cocaine-seeking behavior. Herein, we extended the structure-activity relationships of PSNCBAM-1 (2) at the central phenyl ring directly connected to the urea moiety. Replacement with a thiophene ring led to 11 with improved or comparable potencies in calcium mobilization, [35S]GTPγS binding, and cAMP assays, whereas substitution with nonaromatic rings led to significant attenuation of the modulatory activity. These compounds had no inverse agonism in [35S]GTPγS binding, a characteristic that is often thought to contribute to adverse psychiatric effects. While 11 had good metabolic stability in rat liver microsomes, it showed modest solubility and blood-brain barrier permeability. Compound 11 showed an insignificant attenuation of cocaine seeking behavior in rats, most likely due to its limited CNS penetration, suggesting that pharmacokinetics and distribution play a role in translating the in vitro efficacy to in vivo behavior.