212051-17-7

Basic information

• Product Name: Ethanimidic acid, 2,2,2-trifluoro-, (4-methoxyphenyl)methyl ester
• Synonyms: p-methoxybenzyl trifluoroacetimidate;PMB acetimidate;4-methoxybenzyl trifluoroacetimidate;4-methoxybenzyl 2,2,2-trifluoroacetimidate
• CAS NO: 212051-17-7
• Molecular Formula: C10H10F3NO2
• Molecular Weight: 233.19
• Mol File: 212051-17-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 217.8±50.0 °C(Predicted)
• Density: 1.23±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Ethanimidic acid, 2,2,2-trifluoro-, (4-methoxyphenyl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanimidic acid, 2,2,2-trifluoro-, (4-methoxyphenyl)methyl ester(212051-17-7)
• EPA Substance Registry System: Ethanimidic acid, 2,2,2-trifluoro-, (4-methoxyphenyl)methyl ester(212051-17-7)

Safety Data

• Hazardous Substances Data: 212051-17-7(Hazardous Substances Data)

Upstream product

• 545-06-2 trichloroacetonitrile 
• 105-13-5 4-Methoxybenzyl alcohol 
• 353-85-5 trifluoroacetonitrile 
• 354-38-1 2,2,2-trifluoroacetamide 

Downstream Products

• 212051-35-9 (R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate 
• 121336-29-6 (3aR,5R,6R,6aR)-5-Ethyl-6-(4-methoxy-benzyloxy)-2,2,6-trimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 1450842-79-1 C₂₉H₄₀O₆ 
• 1178903-33-7 6-fluoro-1-(4-methoxybenzyl)-1H-indazole 
• 1178903-44-0 6-fluoro-2-(4-methoxybenzyl)-2H-indazole 
• 1178903-31-5 4-fluoro-1-(4-methoxybenzyl)-1H-indazole 
• 1178903-42-8 4-fluoro-2-(4-methoxybenzyl)-2H-indazole 
• 1178903-39-3 2-(4-methoxybenzyl)-2H-indazole 
• 5363-21-3 1-(4-methoxybenzyl)-1H-indazole 
• 566203-39-2 (-)-1-[3-(4-methoxybenzyloxy)-1-penten-4-yloxycarbonyl]prop-2-yl 5-acryloyloxy-4-[(2-methoxyethoxy)methoxy]-2-hexenoate 
• 655245-29-7 (-)-1-[3-(4-methoxybenzyloxy)-1-penten-4-yloxycarbonyl]prop-2-yl 5-(tert-butyldimethylsilyloxy)-4-[(2-methoxyethoxy)methoxy]-2-hexenoate 
• 655245-26-4 (-)-1-[3-(4-methoxybenzyloxy)-1-penten-4-yloxycarbonyl]prop-2-yl 5-acryloyloxy-4-[(2-methoxyethoxy)methoxy]-2-hexenoate 
• 655245-30-0 (-)-1-[3-(4-methoxybenzyloxy)-1-penten-4-yloxycarbonyl]prop-2-yl 5-hydroxy-4-[(2-methoxyethoxy)methoxy]-2-hexenoate 
• 655245-27-5 (3R,4S)-3-(4-methoxybenzyloxy)-1-penten-4-yl (3R)-3-(tert-butyldimethylsilyloxy)butanoate 

Relevant articles and documents

Synthesis of the C1 – C16 fragment of bryostatin for incorporation into 20,20-fluorinated analogues

The stereoselective synthesis of a carboxylic acid ester corresponding to the C1–C16 fragment of bryostatin, with 4-methoxybenzyl (PMB) protection for the 7-hydroxyl group, is reported. The key steps included a Horner-Wadsworth-Emmons reaction between (5R

Preparation and reaction of 4-methoxybenzyl (MPM) and 3,4- dimethoxybenzyl (DMPM) perfluoroimidates

We have succeeded in one-pot preparation of perfluoroimidates at -78 °C by employing the dehydration of perfluoroamide under the 'activated' dimethyl sulfoxide (DMSO) species followed by in situ nitrile trapping with alcohols. MPM and DMPM perfluoroimidates can be used to protect alcohols in place of the trichloroacetimidate with excellent chemical properties and in comparable yields.