212061-56-8

Basic information

• Product Name: 2'-O-Allyl-5'-O-dimethoxytrityl-5-methyluridine
• Synonyms: 2'-O-Allyl-5'-O-dimethoxytrityl-5-methyluridine
• CAS NO: 212061-56-8
• Molecular Weight: 600.668
• Mol File: 212061-56-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2'-O-Allyl-5'-O-dimethoxytrityl-5-methyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O-Allyl-5'-O-dimethoxytrityl-5-methyluridine(212061-56-8)
• EPA Substance Registry System: 2'-O-Allyl-5'-O-dimethoxytrityl-5-methyluridine(212061-56-8)

Safety Data

• Hazardous Substances Data: 212061-56-8(Hazardous Substances Data)

Downstream Products

• 212061-57-9 2'-O-(2-Hydroxyethyl)-5'-O-dimethoxytrityl-5-methyluridine 

Relevant articles and documents

Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom

Nucleosidic monomers and oligomeric compounds prepared therefrom are provided which have increased nuclease resistance, substituent groups (such as 2′-aminooxy groups) for increasing binding affinity to complementary strand, and regions of 2′-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.

Oligonucleotide analogs having modified dimers

Modified dimers having a ribose sugar moiety in the 5′ nucleoside and a 2′ modified sugar in the 3′ nucleoside are provided. The modified dimers are useful in the preparation of oligonucleotide analogs having enhanced properties compared to native oligonucleotides, including increased nuclease resistance, enhanced binding affinity and improved protein binding.

2'-O-aminooxy-modified oligonucleotides

Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.