21211-20-1 Usage
General Description
Methyl 3-chloro-6-fluorobenzo(b)thiophene is a chemical compound with the molecular formula C9H5ClFS. It is a heterocyclic aromatic compound with a benzothiophene ring that contains a methyl group, a chlorine atom, and a fluorine atom. METHYL 3-CHLORO-6-FLUOROBENZO(B)THIOPHE& has potential applications in the pharmaceutical and agrochemical industries due to its unique structure and properties. However, it is important to handle this chemical with caution as it may have hazardous effects on health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 21211-20-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,1 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 21211-20:
(7*2)+(6*1)+(5*2)+(4*1)+(3*1)+(2*2)+(1*0)=41
41 % 10 = 1
So 21211-20-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H6ClFO2S/c1-14-10(13)9-8(11)6-3-2-5(12)4-7(6)15-9/h2-4H,1H3
21211-20-1Relevant articles and documents
Mild Esterification of Carboxylic Acids via Continuous Flow Diazotization of Amines
Audubert, Clément,Lebel, Hélène
supporting information, p. 4407 - 4410 (2017/08/23)
A new continuous flow protocol for the diazotization of methylamine with 1,3-propanedinitrite in THF is reported. The synthesis of methyl esters was achieved in high yields from a variety of carboxylic acids in 20 min at 90 °C. Additionally, this protocol was extended to other aryl and alkyl amines, namely secondary amines, to produce various substituted esters in high yield using 2-MeTHF as a solvent. The reaction conditions were compatible with many functional groups, namely nitrogen-containing heterocycles, alkynes, alkenes, alcohols, and phenols. Mechanistic investigations reveal that the reaction appears to proceed through a transient diazonium species rather than a diazo intermediate.
