212140-39-1

Basic information

• Product Name: N6-FMoc-D-lysine
• Synonyms: N6-FMoc-D-lysine;N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-lysine
• CAS NO: 212140-39-1
• Molecular Formula: C21H24N2O4
• Molecular Weight: 368.42626
• Mol File: 212140-39-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 609.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.245±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.53±0.24(Predicted)
• CAS DataBase Reference: N6-FMoc-D-lysine(CAS DataBase Reference)
• NIST Chemistry Reference: N6-FMoc-D-lysine(212140-39-1)
• EPA Substance Registry System: N6-FMoc-D-lysine(212140-39-1)

Safety Data

• Hazardous Substances Data: 212140-39-1(Hazardous Substances Data)

Usage

General Description

N6-FMoc-D-lysine is a chemical compound that is used in the synthesis of peptides and other organic molecules. It is a derivative of the amino acid lysine, with a fluorine-modified 6-position and a protecting group in the form of the FMoc (9-fluorenylmethoxycarbonyl) group. N6-FMoc-D-lysine is commonly used in solid-phase peptide synthesis to introduce lysine residues into peptides and to protect the amine group from unwanted reactions. N6-FMoc-D-lysine is an important building block in the production of a wide range of bioactive peptides, pharmaceuticals, and other organic compounds.

Upstream product

• 56-87-1 L-lysine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 201009-98-5 N^ε-(9-fluorenylmethoxycarbonyl)-L-lysine methyl ester hydrochloride 
• 849752-39-2 6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester 
• 84624-27-1 Boc-Lys(Fmoc)-OH 
• 657-26-1 L-lysine dihydrochloride 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 657-27-2 L-Lysine hydrochloride 
• 28920-44-7 (9H-fluoren-9-yl)methyl azidoformate 

Downstream Products

• 186350-56-1 Alloc-L-Lys(N-Fmoc)-OH 
• 183444-90-8 (S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid 
• 84624-27-1 Boc-Lys(Fmoc)-OH 

Relevant articles and documents

A lysoganglioside/poly-L-glutamic acid conjugate as a picomolar inhibitor of influenza hemagglutinin

Based on the principle of a multivalent interaction, the amphiphilic polymer 1, present in solution as an aggregate (see below right), is able to inhibit infection with the influenza virus. After recognition of a specific sialyllactose epitope through hemagglutinin (HA) on the virus surface, the sphingosine residues and the fluorescent tag form a stable complex with HA through hydrophobic interactions. Polymer 1 shows in vitro inhibitory activity 106-fold greater than that of sialyllactose. PGA = polyglutamic acid.

Method for selective structural modification of L-lysine

The invention belongs to the field of chemical synthesis, and particularly relates to a method for selective structural modification of L-lysine. According to a specific technical scheme in the invention, L-lysine is taken as a raw material, silicon dioxide nanoparticles surface-functionalized by beta-cyclodextrin are taken as a catalyst, water is taken as a solvent, and a reaction is performed for 3-5 hours at 25 DEG C in the presence of an amino protective agent to obtain a final product of the reaction; the final reaction product is subjected to standing, and an upper-layer product is takenand subjected to washing, separating and filtering to obtain selectively-modified L-lysine. The used catalyst is odorless and non-toxic; the synthesis method is simple; catalytic performance is excellent; product separation is easy; the catalyst can be repeatedly used; the method effectively solves the problem that a mixture of a common beta-cyclodextrin catalyzed product and cyclodextrin floatson a liquid level and is difficult to separate, simplifies post-treatment steps, reduces the use amount of an organic solvent, and greatly reduces the amount of waste liquid generated in the stage ofpurification.

Decomposition of copper-amino acid complexes by sodium sulfide

Sodium sulfide very efficiently removes copper from protected amino acid-copper complexes. The copper in the amino acid complex was reduced to insoluble cuprous sulfide and the free amino acid was released in pure form. This method is very convenient and rapid, requiring only 5-10 min and 0.55-0.75 equiv of sodium sulfide.