212197-74-5

Basic information

• Product Name: 5-CYANOFURAN-2-CARBOXYLICACID
• Synonyms: 5-CYANOFURAN-2-CARBOXYLICACID;2-Cyano-5-furancarboxylic acid;2-Furancarboxylic acid, 5-cyano-;5-cyano-2-furancarboxylic acid
• CAS NO: 212197-74-5
• Molecular Formula: C₆H₃NO₃
• Molecular Weight: 137.1
• Mol File: 212197-74-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 314℃
• Flash Point: 144℃
• Appearance: /
• Density: 1.47
• Storage Temp.: 2-8°C
• PKA: 2.23±0.10(Predicted)
• CAS DataBase Reference: 5-CYANOFURAN-2-CARBOXYLICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANOFURAN-2-CARBOXYLICACID(212197-74-5)
• EPA Substance Registry System: 5-CYANOFURAN-2-CARBOXYLICACID(212197-74-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 212197-74-5(Hazardous Substances Data)

Usage

General Description

5-Cyanofuran-2-carboxylic acid is a chemical compound characterized by the presence of a cyanide and carboxylic acid group on the furan ring. The furan group, a five-membered aromatic ring with oxygen, is a common unit in various organic compounds, providing potential for wide reactivity. The cyanide group is known for its chemical reactivity, especially in forming carbon-carbon bonds, which makes it valuable in chemical synthesis. The carboxylic acid group further extends its reactivity, notably in forming ester or amide bonds, making the compound of potential interest for reactions in a variety of organic chemical contexts. The specific physical and chemical properties, safety, and uses of this compound would depend on its detailed study and characterization.

Upstream product

• 19158-51-1 P-toluenesulfonyl cyanide 
• 13529-17-4 5-Formyl-2-furancarboxylic acid 
• 54376-30-6 C₆H₅NO₄ 
• 617-90-3 2-furancarbonitrile 
• 124-38-9 carbon dioxide 

Downstream Products

• 852285-83-7 5-Cyano-furan-2-carboxylic acid (2-furan-2-yl-phenyl)-amide 
• 852285-84-8 5-Cyano-furan-2-carboxylic acid (2-furan-3-yl-phenyl)-amide 
• 852285-85-9 5-Cyano-furan-2-carboxylic acid biphenyl-2-ylamide 
• 852285-86-0 5-Cyano-furan-2-carboxylic acid [2-(1H-pyrazol-3-yl)-phenyl]-amide 
• 885703-64-0 5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide 
• 854044-10-3 5-cyano-furan-2-carboxylic acid [2-(4-acetylamino-piperidin-1-yl)-phenyl]-amide 

Relevant articles and documents

Redox-Neutral Photocatalytic C?H Carboxylation of Arenes and Styrenes with CO2

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C-FMS KINASE INHIBITORS

The invention is directed to compounds of Formula II: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE

The invention relates to compounds of Formula (I), wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.