212370-59-7

Basic information

• Product Name: HS024
• Synonyms: HS024;(ACETYL-CYS3,NLE4,ARG5,D-2-NAL7,CYS11)-ALPHA-MSH (3-11) AMIDE TRIFLUOROACETATE SALT;AC-CYS-NLE-ARG-HIS-D-2-NAL-ARG-TRP-GLY-CYS-NH2;AC-CYS-NLE-ARG-HIS-D-2-NAL-ARG-TRP-GLY-CYS-NH2 TRIFLUOROACETATE SALT;AC-CYS-NLE-ARG-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-NH2;(AC-CYS3,NLE4,ARG5,D-ALA(2-NAPHTHYL)7,CYS11)-ALPHA-MSH (3-11) AMIDE;[Acetyl-Cys3, Nle4, Arg5, D-2-Nal7, Cys11]-α-Melanocyte Stimulating Hormone Fragment 3-11 amide;M.W. 1266.50 C58H79N19O10S2
• CAS NO: 212370-59-7
• Molecular Formula: C58H81N19O10S2
• Molecular Weight: 1268.52
• Product Categories: Melanocortin receptor
• Mol File: 212370-59-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.50±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• PKA: 12.79±0.70(Predicted)
• CAS DataBase Reference: HS024(CAS DataBase Reference)
• NIST Chemistry Reference: HS024(212370-59-7)
• EPA Substance Registry System: HS024(212370-59-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 212370-59-7(Hazardous Substances Data)

Usage

General Description

HS024 is a potent and selective inhibitor of the protein kinase DYRK1A, which plays a role in neurodevelopmental disorders such as Down syndrome and Alzheimer's disease. This small molecule has been shown to inhibit DYRK1A activity in cellular and in vivo models, making it a promising candidate for the treatment of cognitive impairment associated with these disorders. HS024 has also demonstrated good oral bioavailability and brain penetration in preclinical studies, making it a potential drug candidate for the treatment of neurological conditions characterized by DYRK1A dysregulation.