2124-57-4 Usage
Description
Vitamin K2(35), also known as menaquinone, is a polyisoprenoid-substituted naphthoquinone that plays a vital role in various physiological processes. Menaquinone 7 (MK-7) is a subtype of vitamin K2, which is primarily produced by bacteria and found in animals, soy protein, and fermented products. MK-7 is a vitamin K2 analog that has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins, such as osteocalcin and matrix-Gla protein, which are crucial for building and maintaining overall bone health.
Uses
Used in Pharmaceutical Industry:
Vitamin K2(35) is used as a prothrombogenic agent for its ability to support blood clotting and prevent hemorrhagic conditions.
Used in Nutritional Supplements:
Vitamin K2(35) is used as a dietary supplement to support bone health and prevent conditions like osteoporosis and extraosseous calcification.
Used in Research and Development:
Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) is used as a stable isotope internal standard for data interpretation in specific biological samples, aiding in the study of vitamin K2's role in various physiological processes.
Used in Food Industry:
Vitamin K2(35) is used as an additive in the food industry to enhance the nutritional value of products and support bone health in consumers.
Chemical Properties:
Vitamin K2(35), specifically MK-7, is a light yellow crystalline solid with unique chemical properties that contribute to its various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 2124-57-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,2 and 4 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2124-57:
(6*2)+(5*1)+(4*2)+(3*4)+(2*5)+(1*7)=54
54 % 10 = 4
So 2124-57-4 is a valid CAS Registry Number.
InChI:InChI=1/C46H64O2/c1-34(2)18-12-19-35(3)20-13-21-36(4)22-14-23-37(5)24-15-25-38(6)26-16-27-39(7)28-17-29-40(8)32-33-42-41(9)45(47)43-30-10-11-31-44(43)46(42)48/h10-11,18,20,22,24,26,28,30-32H,12-17,19,21,23,25,27,29,33H2,1-9H3/b35-20+,36-22+,37-24+,38-26+,39-28+,40-32+
2124-57-4Relevant articles and documents
PROCESS OF VITAMIN K2 DERIVATIVES PREPARATION
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, (2021/04/17)
The invention relates to an improved process of vitamin K2 derivatives preparation via the alkylation of the menadione-cyclopentadiene adduct.
PROCESS OF VITAMIN K2 DERIVATIVES PREPARATION
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, (2019/10/29)
Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13.
Convergent synthesis of menaquinone-7 (MK-7)
Baj, Aneta,Wa?ejko, Piotr,Kutner, Andrzej,Kaczmarek, L?ukasz,Morzycki, Jacek W,Witkowski, Stanisl?aw
, p. 1026 - 1033 (2017/01/16)
A practical synthesis of menaquinone-7 (MK-7, vitamin K2) in the all-Trans form was designed. Stereoselective synthesis of MK-7 was achieved through a "1 + 6" convergent strategy by condensation of two building blocks, menadione monoprenyl derivative (fragment "1") with hexaprenyl bromide (fragment "6", 82%). Pd-catalyzed desulfonation with LiEt3BH (78%) was followed by oxidation of the hydroquinone moiety using ammonium cerium(IV) nitrate (72%). The major challenge in our methodology was the preparation of all-Trans hexaprenyl bromide by coupling of two triprenyl units derived from trans,trans-farnesol. Manufacturing on a pilot scale was accomplished through our approach. The scalable method was designed especially for a large, kilogram-scale production from easily available intermediates. Furthermore, the proposed methodology avoids many chromatographic purifications and allows for a relatively cost-effective manufacturing. Moreover, our synthesis yielded high-purity (99.9%) final product MK-7, which can be used as a dietary supplement as well as an active pharmaceutical ingredient.