212651-48-4

Basic information

• Product Name: FMOC-GLY-PRO-OH
• Synonyms: FMOC-GLY-PRO-OH;FMOC-GLYCYL-L-PROLINE;Fmoc-Gly-Pro-OH≥ 98% (HPLC);Fmoc-gycyl-L-proline;(9H-Fluoren-9-yl)MethOxy]Carbonyl Gly-Pro-OH
• CAS NO: 212651-48-4
• Molecular Formula: C₂₂H₂₂N₂O₅
• Molecular Weight: 394.42
• Product Categories: Amino Acid Derivatives
• Mol File: 212651-48-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 676.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.346±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.50±0.20(Predicted)
• CAS DataBase Reference: FMOC-GLY-PRO-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-GLY-PRO-OH(212651-48-4)
• EPA Substance Registry System: FMOC-GLY-PRO-OH(212651-48-4)

Safety Data

• Hazardous Substances Data: 212651-48-4(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 704-15-4 H-Gly-Pro-OH 
• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 71989-31-6 Fmoc-Pro-OH 

Downstream Products

• 704-15-4 H-Gly-Pro-OH 

Relevant articles and documents

Use of an internal reference for the quantitative HPLC-UV analysis of solid-phase reactions: A case study of 2-chlorotrityl chloride resin

Here we evaluated the use of internal reference compounds for the rapid assessment of reactions performed in solid-phase. An internal reference compound (commercially available) was bound to the resin, together with the substrate, and cleaved with the products after completion of the reaction. The peak area of the reference compound in the HPLC-UV chromatograms can be correlated directly with those of other compounds present in the reaction mixture, thereby allowing a quantitative interpretation of the chromatograms with respect to conversion and yield. The usefulness of this method was demonstrated by optimization of a protocol for the synthesis of proline-based tripeptides.

Peptide bond isosteres: Ester or (E)-alkene in the backbone of the collagen triple helix

(Chemical Equation Presented) Collagen is the most abundant protein in animals. Interstrand N-H...O=C hydrogen bonds between backbone amide groups form a ladder in the middle of the collagen triple helix. Isosteric replacement of the hydrogen-bond-donatin