21269-13-6Relevant articles and documents
TRANSFORMED STEROIDS. IODOSOBENZENE DIACETATE FOR THE α-HYDROXYLATION OF -2'-METHYLOXAZOLINE DERIVATIVES OF 20-KETOSTEROIDS
Kamernitskii, A. V.,Turuta, A. M.,Fadeeva, T. M.,Korobov, A. A.,Terekhina, A. I.,Gritsina, T. I.
, p. 694 - 696 (2007/10/02)
Using the -2'-methyloxazoline derivatives of 3β-hydroxypregn-5-en-20-one (I) as an example, the α-hydroxylation reaction has been studied with the use of iodosobenzene diacetate in a methanolic solution of NaOH as the α-hydroxylating reagent.The reaction took place successfully through the stage of the formation and isolation of the corresponding -2'-methyloxazoline derivative of 20,20-dimethylpregn-15-ene-3β,21-diol (II), the dimethyl acetal protection of which was eliminated by acid hydrolysis in methanol.The results of physicochemical investigations and biological trials of the -2'-methyloxazoline derivatives of 21-hydroxy-21-acetoxy-20-ketosteroids obtained are given.