21306-56-9

Basic information

• Product Name: QX-314
• Synonyms: 2-[(2,6-Dimethylphenyl)amino]-N,N,N-triethyl-2-oxoethanaminium;QX-314.Br;QX-314 bromide (N-Ethyllidocaine bromide);N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM BROMIDE;N-(2,6-DIMETHYLPHENYL)ACETAMIDE-2-TRIETHYLAMMONIUM BROMIDE;QX-314;QX 314 BROMIDE;LIDOCAINE N-ETHYL BROMIDE
• CAS NO: 21306-56-9
• Molecular Formula: C16H27BrN2O
• Molecular Weight: 343.3
• Product Categories: Sodium channel;Ion Channels
• Mol File: 21306-56-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Desiccate at RT
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: QX-314(CAS DataBase Reference)
• NIST Chemistry Reference: QX-314(21306-56-9)
• EPA Substance Registry System: QX-314(21306-56-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 21306-56-9(Hazardous Substances Data)

Usage

Description

QX-314 is a derivative of Lidocaine, a well-known local anesthetic. It is a quaternary ammonium compound that is highly charged and hydrophilic, making it impermeable to cell membranes. This unique property allows QX-314 to be used as a blocker of voltage-activated sodium channels, which play a crucial role in the generation and propagation of action potentials in nerve cells.

Uses

Used in Neuroscience Research:
QX-314 is used as a blocker of voltage-activated sodium channels for studying the function and behavior of neurons. By inhibiting the activity of these channels, researchers can gain insights into the mechanisms underlying neuronal excitability and signal transmission.
Used in Local Anesthesia:
As a derivative of Lidocaine, QX-314 is used as a local anesthetic to provide pain relief during medical procedures. Its ability to block voltage-activated sodium channels in nerve cells helps to prevent the transmission of pain signals to the brain, thus offering temporary pain relief.
Used in Drug Delivery Systems:
QX-314 bromide can be used in drug delivery systems to improve the targeting and efficacy of various therapeutic agents. Its hydrophilic nature and inability to cross cell membranes can be leveraged to develop novel drug delivery platforms that selectively deliver drugs to specific cells or tissues, enhancing their therapeutic potential while minimizing side effects.

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.

InChI:InChI=1/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H