213192-56-4

Basic information

• Product Name: 3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID
• Synonyms: RARECHEM AK HW 0215;3-AMINO-3-[4-(TRIFLUOROMETHOXY)PHENYL]PROPANOIC ACID;3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID
• CAS NO: 213192-56-4
• Molecular Formula: C₁₀H₁₀F₃NO₃
• Molecular Weight: 249.19
• Mol File: 213192-56-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 314.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.398±0.06 g/cm3(Predicted)
• PKA: 3.59±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID(213192-56-4)
• EPA Substance Registry System: 3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID(213192-56-4)

Safety Data

• Hazardous Substances Data: 213192-56-4(Hazardous Substances Data)

Usage

General Description

3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID is a chemical compound with the molecular formula C10H11F3NO3. It is a derivative of the amino acid phenylalanine, containing an additional amino and carboxylic acid group. 3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID is often used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its unique structure and properties. It has been studied for its potential pharmacological applications, particularly in the development of new drugs for various medical conditions. Additionally, it is known for its role in organic chemistry as a building block for the synthesis of more complex molecules.

Upstream product

• 141-82-2 malonic acid 
• 659-28-9 p-trifluoromethoxybenzaldehyde 

Downstream Products

• 287959-34-6 methyl 3-amino-3-(4-trifluoromethoxyphenyl)propionate 
• 288848-61-3 3-(4-trifluoromethoxyphenyl)-3-pyrrol-1-ylpropionic acid 
• 288848-62-4 N-(3-(4-trifluoromethoxyphenyl)-3-pyrrol-1-ylpropionyl)pyrrolidine 
• 288848-58-8 3-(4-trifluoromethoxyphenyl)-2,3-dihydro-1H-pyrrolizin-1-one 
• 320727-89-7 3-[N-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-3-(4-trifluoromethoxy)-phenylpropionic acid 

Relevant articles and documents

β-alanine derivatives

The invention relates to β-alanine derivatives of formula (I), wherein Q1, Q2, Q3, Q4, R1, R2, R3, R4, R5, R6and n have the meaning as disclosed

Solid-phase synthesis of a nonpeptide RGD mimetic library: New selective αvβ3 integrin antagonists

The solid-phase synthesis of a low molecular weight RGD mimetic library is described. Activities of the compounds in inhibiting the interaction of ligands, vitronectin and fibrinogen, with isolated immobilized integrins αvβ3 and αIIbβ3 were determined in a screening assay. Highly active and selective nonpeptide αvβ3 integrin antagonists with regard to orally bioavailability were developed, based on the aza-glycine containing lead compound 1. An important variation is the substitution of the aspartic amide of 1 by an aromatic residue. Furthermore, different guanidine mimetics have been incorporated to improve the pharmacokinetic profile. Exchange of the β-amino acid NH by a methylene moiety in one set of RGD mimetics leads to the azacarba analogue compounds representing a novel peptidomimetic approach, which should increase the metabolic stability.