213686-58-9

Basic information

• Product Name: (+)-benzyl N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat
• Synonyms: (+)-benzyl N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat
• CAS NO: 213686-58-9
• Molecular Weight: 547.692
• Mol File: 213686-58-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+)-benzyl N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-benzyl N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat(213686-58-9)
• EPA Substance Registry System: (+)-benzyl N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>carbamat(213686-58-9)

Safety Data

• Hazardous Substances Data: 213686-58-9(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 213686-76-1 (S)-(+)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydrylamine 
• 99267-98-8 (2R,3R)-1,4-dimethoxy-1,1,4,4-tetramethyl-2,3-butanediol 
• 112396-13-1 2-(2-bromophenyl)acetaldehyde dimethyl acetal 
• 213686-67-0 (+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide 
• 172794-67-1 (4R,5R)-2-(2-Bromo-benzyl)-4,5-bis-(1-methoxy-1-methyl-ethyl)-[1,3]dioxolane 
• 51608-60-7 phenyl N-tosyl imine 
• 207615-45-0 benzaldehyde N-(benzyloxycarbonyl)imine 

Downstream Products

• 99267-98-8 (2R,3R)-1,4-dimethoxy-1,1,4,4-tetramethyl-2,3-butanediol 
• 172794-79-5 (S)-(-)-benzyl 1-phenyl-1,2-dihydroisoquinoline-2-carboxylate 

Relevant articles and documents

Investigation of the diastereoselectivity during the addition of an enantiomerically pure (2-lithiophenyl)acetaldehyde acetal to various imines

The diastereoselectivity during the addition of the homochiral (2-lithiophenyl)acetaldehyde acetal 1b to various imine components was investigated. The diastereoselectivity could be raised to 84.2% de by addition of 1b to benzylidenanisidine 2h. Removal of the tosyl and the p-methoxyphenyl protective groups of 3c, 4c and 3h/4h succeeded with sodium in liquid ammonia and ammonium cerium(IV) nitrate, respectively, to yield the enantiopure benzhydrylamines 5 and 6.

Asymmetric synthesis of 1-aryl-1,2,3,4-tetrahydroisoquinolines part 1: Addition of chiral phenylacetaldehyde acetals to acylimines

The stereoselectivity in the addition of the enantiomerically pure (2-bromophenyl)acetaldehyde acetals 3a-g to the acylimines 4a,b is investigated. Based on this reaction a novel asymmetric synthesis for the 1-phenyl-tetrahydroisoquinoline 8 is elaborated.