2138-20-7

Basic information

• Product Name: 4-CYCLOHEXYLRESORCINOL
• Synonyms: 1,3-Benzenediol, 4-cyclohexyl-;4-Cyclohexyl-1,3-benzenediol;4-CYCLOHEXYLRESORCINOL;4-Cyclohexyl-1,3-resorcinol;4-CYCLOHEXYLRESORCINOL 97%;4-cyclohexylbenzene-1,3-diol
• CAS NO: 2138-20-7
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25
• EINECS: 218-380-3
• Mol File: 2138-20-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 124 °C
• Boiling Point: 288.25°C (rough estimate)
• Flash Point: 170.6°C
• Appearance: /
• Density: 1.0240 (rough estimate)
• Vapor Pressure: 2.09E-05mmHg at 25°C
• Refractive Index: 1.5100 (estimate)
• PKA: 9.99±0.18(Predicted)
• Water Solubility: 499.8mg/L(25 oC)
• CAS DataBase Reference: 4-CYCLOHEXYLRESORCINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYCLOHEXYLRESORCINOL(2138-20-7)
• EPA Substance Registry System: 4-CYCLOHEXYLRESORCINOL(2138-20-7)

Safety Data

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
• Hazardous Substances Data: 2138-20-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 2225, 1951 DOI: 10.1021/ja01149a088

InChI:InChI=1/C12H16O2/c13-10-6-7-11(12(14)8-10)9-4-2-1-3-5-9/h6-9,13-14H,1-5H2

Upstream product

• 108-93-0 cyclohexanol 
• 108-46-3 recorcinol 
• 873399-89-4 2,4-dichloro-6-cyclohexyl-resorcinol 
• 110-83-8 cyclohexene 
• 542-18-7 cyclohexyl chloride 
• 37470-92-1 4-chloro-6-cyclohexyl-resorcinol 

Downstream Products

• 4396-96-7 bicyclohexyl-2,4-dione 
• 873399-90-7 2-chloro-4-cyclohexyl-resorcinol 
• 37470-92-1 4-chloro-6-cyclohexyl-resorcinol 
• 409317-43-7 4-cyclohexyl-6-nitroso-resorcinol 
• 159977-40-9 5-cyclohexyl-2,4-dihydroxy-deoxybenzoin 
• 717917-51-6 3-cyclohexyl-2,6-dihydroxy-deoxybenzoin 
• 119415-24-6 2',7'-dicyclohexyl-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one 
• 1350472-39-7 1,3-bis(dibenzylphosphonooxy)-4-cyclohexylbenzene 
• 65240-37-1 1-{5-Cyclohexyl-3-[3-cyclohexyl-2,6-dihydroxy-5-(2,2,2-trifluoro-acetyl)-benzyl]-2,4-dihydroxy-phenyl}-2,2,2-trifluoro-ethanone 
• 119505-87-2 4',5'-dibromo-2',7'-dicyclohexyl-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one 
• 129046-56-6 2-cyclohexyl-5-hydroxy-[1,4]benzoquinone 

Relevant articles and documents

Cyclohexylation of resorcinol with cyclohexanol catalyzed by tungstophosphoric acid supported zirconia catalysts

We demonstrate a highly active and reusable heterogeneous catalyst system, tungstophosphoric acid (TPA) supported on zirconia (ZrO2), for the cyclohexylation of resorcinol by cyclohexanol to produce value added chemicals such as 2-cyclohexyl resorcinol, 4-cyclohexyl resorcinol and 3-Hydroxy cyclohexyl phenyl ether under liquid phase reaction condition. TPA/ZrO2 catalysts prepared with different TPA loadings (5-30 wt.%) by wet impregnation method and calcined in the temperature range of 650-850°C were characterized by Nitrogen sorption analysis, XRD, FTIR, DTG and DTA, and 31P MAS NMR spectroscopy. Among the catalysts studied, 15 wt.%TPA/ZrO2 catalyst calcined at 750°C gave the highest conversion of resorcinol (51.2%) with the selectivities for 3-Hydroxy cyclohexyl phenyl ether (53.9%) and 2-cyclohexyl resorcinol and 4-cyclohexyl resorcinol together (46.1%) under optimum reaction conditions. However, the selectivity of the products were controlled by varying the reaction conditions. At higher conversion of resorcinol (78.9%), only C-alkylated products were formed at 200°C with 15 wt.%TPA/ZrO2 catalyst calcined at 750°C. The combination of TPA and ZrO2 coupled with calcination temperature offered an excellent platform for the conversion of resorcinol into O-or C-alkylated products.

Synthesis of cyclohexylphenols

Catalytic alkylation of phenols with cyclohexanol gives o- and p-cyclohexylphenols as the major products. The effect of temperature, catalyst nature, and reactant concentration on the reaction outcome was studied.

Resorcinol derivatives

The present invention relates to the use of certain resorcinol derivatives as skin lightening agents.