2138811-33-1 Usage
Description
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester; compound with (E)-but-2-enedioic acid is a complex organic compound with a unique chemical structure. It is derived from the salt form of 3-Ethyl 5-methyl 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methylpyridine-3,5-dicarboxylate, which is an impurity found in levamlodipine besylate tablets. 2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester; compound with (E)-but-2-enedioic acid has a potential application in the pharmaceutical industry due to its association with a widely used medication.
Uses
Used in Pharmaceutical Industry:
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester; compound with (E)-but-2-enedioic acid is used as an impurity in the production of levamlodipine besylate tablets. Levamlodipine besylate is a medication used to treat hypertension (high blood pressure) and is known for its long-lasting effects. The presence of this compound as an impurity may have implications for the quality control and safety of the final product, making it an important consideration in the pharmaceutical manufacturing process.
Check Digit Verification of cas no
The CAS Registry Mumber 2138811-33-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,1,3,8,8,1 and 1 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2138811-33:
(9*2)+(8*1)+(7*3)+(6*8)+(5*8)+(4*1)+(3*1)+(2*3)+(1*3)=151
151 % 10 = 1
So 2138811-33-1 is a valid CAS Registry Number.
2138811-33-1Relevant articles and documents
Biotransformation of amlodipine. Identification and synthesis of metabolites found in rat, dog and human urine / confirmation of structures by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry
Beresford,Macrae,Alker,Kobylecki
, p. 201 - 209 (2007/10/02)
Metabolism of the dihydropyridine calcium antagonist (R,S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5 methoxycarbonyl-6-methyl-1,4-dihydropyridine (amlodipine) has been studied in animals and man using 14C-labelled drug. The metabolite patterns are complex; 18 metabolites have been isolated from rat, dog and human urine. Based on chromatographic and mass-spectral evidence, structures have been proposed for the main metabolites and confirmed by synthesis of unambiguous reference compounds.
