2140-69-4 Usage
Description
3-METHYL URIDINE, also known as 3-methyluridine, is a modified nucleoside found in RNA molecules. It plays a crucial role in various biological processes, including RNA stability, splicing, and translation. Its unique chemical structure allows it to be selectively detected and analyzed, making it a valuable tool in the study of RNA biology.
Uses
Used in Biological Research:
3-METHYL URIDINE is used as a biomarker for studying RNA modifications, providing insights into the role of ribonucleoside modifications in cellular processes and their potential involvement in diseases.
Used in Analytical Chemistry:
3-METHYL URIDINE is used as an analytical target for comprehensive profiling of ribonucleosides modification. It is detected and analyzed using affinity zirconium oxide-silica composite monolithic column online solid-phase microextraction-mass spectrometry analysis, allowing for the identification and quantification of this modified nucleoside in various samples.
Used in Pharmaceutical Development:
3-METHYL URIDINE can be employed as a target for drug discovery and development, as modulating its levels or activity may have therapeutic potential in treating diseases associated with RNA dysregulation.
Used in Diagnostic Applications:
3-METHYL URIDINE can be utilized as a diagnostic marker for certain diseases, as its levels may be altered in specific pathological conditions. Detection of this modified nucleoside can aid in the diagnosis and monitoring of these diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 2140-69-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,4 and 0 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2140-69:
(6*2)+(5*1)+(4*4)+(3*0)+(2*6)+(1*9)=54
54 % 10 = 4
So 2140-69-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O6/c1-11-6(14)2-3-12(10(11)17)9-8(16)7(15)5(4-13)18-9/h2-3,5,7-9,13,15-16H,4H2,1H3
2140-69-4Relevant articles and documents
Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth—Generation by Prebiotic Methylations and Carbamoylations
Schneider, Christina,Becker, Sidney,Okamura, Hidenori,Crisp, Antony,Amatov, Tynchtyk,Stadlmeier, Michael,Carell, Thomas
supporting information, p. 5943 - 5946 (2018/04/30)
The RNA-world hypothesis assumes that life on Earth started with small RNA molecules that catalyzed their own formation. Vital to this hypothesis is the need for prebiotic routes towards RNA. Contemporary RNA, however, is not only constructed from the four canonical nucleobases (A, C, G, and U), it also contains many chemically modified (noncanonical) bases. A still open question is whether these noncanonical bases were formed in parallel to the canonical bases (chemical origin) or later, when life demanded higher functional diversity (biological origin). Here we show that isocyanates in combination with sodium nitrite establish methylating and carbamoylating reactivity compatible with early Earth conditions. These reactions lead to the formation of methylated and amino acid modified nucleosides that are still extant. Our data provide a plausible scenario for the chemical origin of certain noncanonical bases, which suggests that they are fossils of an early Earth.
SELECTIVE METHYLATION OF NUCLEOSIDES
Pettit, George R.,Yamauchi, Kiyoshi,Einck, James J.
, p. 25 - 36 (2007/10/02)
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