214139-28-3 Usage
Description
N-FMOC-DL-1-AMINOINDANE-1-CARBOXYLIC ACID, also known as N-(9-fluorenylmethoxycarbonyl)-DL-1-aminoindane-1-carboxylic acid, is a white fine crystalline powder with specific chemical properties. It is a synthetic compound that plays a significant role in the development of pharmaceuticals and biochemistry.
Uses
Used in Pharmaceutical Industry:
N-FMOC-DL-1-AMINOINDANE-1-CARBOXYLIC ACID is used as a key intermediate compound for the synthesis of various pharmaceuticals. Its chemical structure allows it to be a building block in the creation of complex molecules with specific biological activities.
Used in Biochemical Research:
In the field of biochemistry, N-FMOC-DL-1-AMINOINDANE-1-CARBOXYLIC ACID is used as a reagent for the preparation of inhibitors that target the interaction between individual nuclear hormone receptors and the mutually shared steroid receptor coactivator 2. This interaction plays a crucial role in various cellular processes, and modulating it can have therapeutic implications for treating certain diseases.
Used in Drug Development:
N-FMOC-DL-1-AMINOINDANE-1-CARBOXYLIC ACID is also utilized in drug development as a precursor for designing and synthesizing novel compounds with potential therapeutic applications. Its unique structure and properties make it a valuable tool for medicinal chemists in their quest to discover new drugs and treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 214139-28-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,1,3 and 9 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 214139-28:
(8*2)+(7*1)+(6*4)+(5*1)+(4*3)+(3*9)+(2*2)+(1*8)=103
103 % 10 = 3
So 214139-28-3 is a valid CAS Registry Number.
InChI:InChI=1/C25H21NO4/c27-23(28)25(14-13-16-7-1-6-12-22(16)25)26-24(29)30-15-21-19-10-4-2-8-17(19)18-9-3-5-11-20(18)21/h1-12,21H,13-15H2,(H,26,29)(H,27,28)/p-1/t25-/m1/s1
214139-28-3Relevant articles and documents
Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2
Geistlinger, Timothy R.,Guy, R. Kiplin
, p. 6852 - 6853 (2007/10/03)
Nuclear hormone receptor (NR) signaling, currently a therapeutic target in multiple diseases, involves an ordered series of protein interactions to regulate transcription in response to changing hormone levels. Later steps in the process of ligand-dependent signaling are driven by a highly conserved interaction between the NRs and the steroid receptor coactivators (SRCs) that is effected by a conserved interaction motif (L1XXL2L3), known as an NR box. Using computational design and combinatorial chemistry, we have produced novel ∞-helical proteomimetics of the second NR box of SRC2 that exploit structural differences between human estrogen receptor ∞ (hER∞), human estrogen receptor β (hERβ), and human thyroid hormone receptor β (hTRβ). The resulting library sequentially replaced each leucine with non-natural side chains. Screening this library using a quantitative competition assay revealed compounds that selectively inhibit the interaction of SRC2-2 with each individual NR in preference to its interaction with the other NR. This approach generated highly selective compounds from one that had no specificity for a particular family member. These compounds represent the first family-member-selective competitive inhibitors of the protein interactions of transcription factors. Copyright
