21427-61-2

Basic information

• Product Name: 5-Chloro-2-hydroxy-3-nitropyridine
• Synonyms: 5-CHLORO-2-HYDROXY-3-NITROPYRIDINE;5-CHLORO-3-NITROPYRIDIN-2-OL;5-CHLORO-3-NITRO-2-PYRIDINOL;2-hydroxy-3-nitro-5-chloropyridine;5-Chloro-3-nitropyridin-2-ol, 95+%;5-Chloro-2-hydroxy-3-nitropyridine 95+%;5-Chloro-2-hydroxy-3-nitropyridine ,97%;2-Hydroxy-5-chloro-3-nitropyridine
• CAS NO: 21427-61-2
• Molecular Formula: C₅H₃ClN₂O₃
• Molecular Weight: 174.54
• EINECS: -0
• Product Categories: blocks;NitroCompounds;Pyridines;Pyridine;Chloropyridines;Halopyridines;Bases & Related Reagents;Nucleotides;Heterocycle-Pyridine series
• Mol File: 21427-61-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 234 °C
• Boiling Point: 316 °C at 760 mmHg
• Flash Point: 125.6 °C
• Appearance: yellow solid
• Density: 1.664 g/cm³
• Vapor Pressure: 0.00303mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Dimethylformamide
• PKA: 6.31±0.10(Predicted)
• BRN: 383852
• CAS DataBase Reference: 5-Chloro-2-hydroxy-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-hydroxy-3-nitropyridine(21427-61-2)
• EPA Substance Registry System: 5-Chloro-2-hydroxy-3-nitropyridine(21427-61-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39-36-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 21427-61-2(Hazardous Substances Data)

Usage

Description

5-Chloro-2-hydroxy-3-nitropyridine, with the CAS number 21427-61-2, is an organic compound characterized by its white to light brown solid appearance. It is known for its utility in various organic synthesis processes, making it a valuable component in the field of chemistry.

Uses

Used in Organic Synthesis:
5-Chloro-2-hydroxy-3-nitropyridine is used as a synthetic building block for the creation of more complex organic molecules. Its unique structure and reactivity allow it to be a versatile component in the synthesis of various compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Chloro-2-hydroxy-3-nitropyridine is used as an intermediate in the development of new drugs. Its specific functional groups and properties make it a suitable candidate for the synthesis of novel therapeutic agents, potentially leading to the discovery of new medications with improved efficacy and safety profiles.
Used in Agrochemical Industry:
5-Chloro-2-hydroxy-3-nitropyridine also finds application in the agrochemical industry, where it is utilized in the synthesis of new pesticides and other crop protection agents. Its incorporation into these products can contribute to the development of more effective and environmentally friendly solutions for agricultural challenges.
Used in Research and Development:
In addition to its practical applications, 5-Chloro-2-hydroxy-3-nitropyridine is also used in research and development settings. Scientists and researchers employ this compound to study its chemical properties, reactivity, and potential applications in various fields, further expanding the knowledge base and driving innovation in chemistry and related industries.

InChI:InChI=1/C5H3ClN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9)

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 5409-39-2 2-amino-5-chloro-3-nitropyridine 
• 4214-79-3 5-chloro-1,2-dihydropyridin-2-one 
• 4214-79-3 5-chloro-2-pyridinol 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 

Downstream Products

• 98027-36-2 3-amino-5-chloro-2-hydroxypyridine 
• 22353-46-4 5-chloro-2-hydrazino-3-nitropyridine 
• 1443995-75-2 C₂₁H₂₅ClN₄O₄ 
• 1443995-76-3 C₂₆H₃₄ClN₅O₅ 
• 1407542-46-4 C₁₆H₁₇ClN₄O₂ 
• 1408054-69-2 C₂₁H₂₆ClN₅O₃ 
• 1441762-33-9 5-chloro-1-(4-methoxy-benzyl)-3-nitro-1H-pyridin-2-one 
• 1441762-26-0 3-amino-5-chloro-1-(4-methoxy-benzyl)-1H-pyridin-2-one 
• 1620583-26-7 ethyl 2-bromo-5-((5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)(4-chloro-3-fluorophenyl)methyl)-1-isopropyl-1H-imidazole-4-carboxylate 
• 1441769-24-9 3-amino-5-chloro-1-methyl-1H-pyridin-2-one 
• 1448870-68-5 2-bromo-5-[(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 1355342-91-4 N-[2-[[1-[2-(4-bromophenoxy)ethyl]-3-azetidinyl]oxy]-5,6-dichloro-3-pyridinyl]-2-chloro-4-pyridinecarboxamide 
• 1355342-90-3 2-chloro-N-[5-chloro-2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-3-pyridinyl]-4-pyridinecarboxamide 
• 21427-62-3 2,5-dichloro-3-nitropyridine 

Relevant articles and documents

Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors

New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 μM). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.

Process for the preparation of (3-fluoropyridin-2-yloxy)phenoxypropionic acids

(3-Fluoropyridin-2-yloxy)phenoxypropionic acids of formula I STR1 wherein X is hydrogen, fluoro, chloro, bromo or trifluoromethyl and Y is hydrogen, sodium or potassium, are prepared by reacting a compound of formula II STR2 wherein X and Y are as defined for formula I, in an anhydrous mixture of hydrogen fluoride, dimethylsulfoxide and a diazotising agent under normal pressure, and converting the diazonium fluoride so produced by thermal decomposition into the (3-fluoropyridin-2-yloxy)phenoxypropionic acid of formula I.