214360-49-3Relevant articles and documents
Highly regioselective Ru(II)-catalyzed [3+2] spiroannulation of 1-aryl-2-naphthols with alkynes via a double directing group strategy
Hao, Jiamao,Ge, Yicong,Yang, Liuqing,Wang, Jing,Luan, Xinjun
supporting information, (2021/04/19)
A highly regioselective Ru(II)-catalyzed [3+2] spiroannulation of 1-aryl-2-naphthols with internal alkynes was developed by using a novel double directing group strategy. This method was compatible with many functional groups, thus affording a variety of sterically congested spirocyclic molecules in high yields.
Controllable factors of supported IR complex catalysis for aromatic C?H borylation
Chun, Wang-Jae,Maeda, Kyogo,Manaka, Yuichi,Motokura, Ken,Nakajima, Kiyotaka,Satter, Shazia Sharmin,Uemura, Yohei
, p. 14552 - 14559 (2020/12/21)
We have developed a catalyst in which an Ir complex and organic functionalities are coimmobilized on the silica surface. The catalytic activity for aromatic C?H borylation was significantly affected by (i) the linker length of the Ir?bipyridine complex, (ii) the coimmobilized organic functionality, and (iii) the substituents on the aromatic substrate compounds. The fine-tuned supported catalyst showed higher activity than the homogeneous Ir?bipyridine complex when using a specific substrate such as benzonitrile. We elucidated this property by conducting solid-state NMR, FT-IR, XAFS, and in situ FT-IR analysis.
Novel Bruton's tyrosine kinase inhibitor as well as preparation method and application thereof
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Paragraph 0198-0203, (2018/07/30)
The invention relates to a reversible novel Bruton's tyrosine kinase inhibitor which comprises a compound of a formula (I) as shown in the specification, and a stereisomer, a aquo-complex, a solvent compound, a pharmaceutically acceptable salt, an eutectic crystal or a predrug of the compound. The invention further relates to a preparation method of the compound and a method and the application ofthe novel compound in inhibiting BTK (Bruton's Tyrosine Kinase) kinase activity and mutant BTK kinase activity.