214485-59-3

Basic information

• Product Name: 3-Quinolinecarbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-nitro-
• CAS NO: 214485-59-3
• Molecular Formula: C17H10ClFN4O3
• Molecular Weight: 372.743
• Mol File: 214485-59-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-nitro-(214485-59-3)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-nitro-(214485-59-3)

Safety Data

• Hazardous Substances Data: 214485-59-3(Hazardous Substances Data)

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 214470-33-4 4-chloro-7-methoxy-6-nitro-quinoline-3-carbonitrile 
• 19861-62-2 2,4-dichloro-5-nitrobenzoic acid 
• 90564-41-3 2,4-dimethoxy-5-nitrobenzoic acid 
• 214470-27-6 7-methoxy-4-hydroxy-6-nitroquinoline-3-carbonitrile 
• 214470-27-6 1,4-dihydro-7-methoxy-6-nitro-4-oxo-quinoline-3-carbonitrile 
• 536-90-3 m-Anisidine 
• 71083-64-2 1,4-dihydro-7-methoxy-4-oxo-quinoline-3-carbonitrile 

Downstream Products

• 214485-60-6 6-amino-4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinoline-3-carbonitrile 

Relevant articles and documents

4-quinazoline amine derivatives and their use

A 4-quinazoline amine derivative as represented by formula (1), a pharmaceutical composition comprising the derivative, and an application thereof in preparing medicine for curing cancer. The cancer is a drug-resistant cancer, preferably a cancer resisting an EGFR reversible inhibitor, and more preferably, a cancer resisting gefitinib, erlotinib or lapatinib; alternatively, the cancer carries EGFR mutation.

USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS

This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula (1); wherein R1, R2, R3, R4, X, Y, and n are defined hereinbefore, or a pharmaceutically acceptable salt thereof.

TRICYCLIC PROTEIN KINASE INHIBITORS

This invention provides compounds of Formula (I), where A'', Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.