214492-05-4

Basic information

• Product Name: (4R,5S)-4-methyl-5-phenyl-3-((2S)-phenylpropionyl)oxazolidin-2-one
• Synonyms: (4R,5S)-4-methyl-5-phenyl-3-((2S)-phenylpropionyl)oxazolidin-2-one
• CAS NO: 214492-05-4
• Molecular Weight: 309.365
• Mol File: 214492-05-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4R,5S)-4-methyl-5-phenyl-3-((2S)-phenylpropionyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-4-methyl-5-phenyl-3-((2S)-phenylpropionyl)oxazolidin-2-one(214492-05-4)
• EPA Substance Registry System: (4R,5S)-4-methyl-5-phenyl-3-((2S)-phenylpropionyl)oxazolidin-2-one(214492-05-4)

Safety Data

• Hazardous Substances Data: 214492-05-4(Hazardous Substances Data)

Upstream product

• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 
• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 
• 219951-25-4 (+/-)-pentafluorophenyl 2-phenylpropionate 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 492-37-5 hydratropic acid 
• 25145-43-1 2-phenylpropionyl chloride 

Downstream Products

• 37778-99-7 (S)-2-phenyl-1-propanol 

Relevant articles and documents

Investigations into the parallel kinetic resolution of 2-phenylpropanoyl chloride using quasi-enantiomeric oxazolidinones

The resolution of 2-phenylpropanoyl chloride using an equimolar combination of quasi-enantiomeric oxazolidinones is discussed. The levels of diastereoselectivity were found to be dependent upon the structural nature of the metallated oxazolidinone, temperature and metal counter-ion.

Resolution of pentafluorophenyl esters using oxazolidin-2-ones

A series of structurally related racemic pentafluorophenyl active esters were resolved using an equimolar amount of (S)-4-phenyloxazolidin-2-one. The levels of diastereocontrol were found to be excellent (80-96% de) at ～40% conversion.