214544-31-7Relevant articles and documents
An efficient substitution reaction for the preparation of thyroid hormone analogues
Yoshihara, Hikari A. I.,Chiellini, Grazia,Mitchison, Timothy J.,Scanlan, Thomas S.
, p. 1179 - 1183 (1998)
The substitution of the sterically hindered carbon of the potent thyroid hormone agonist, GC-1, was effected by a reaction based on the solvolysis of the benzylic hydroxyl group. The reaction was found to proceed in high yield with a variety of nucleophiles including alcohols, thiols, allyl silanes and electron-rich aromatic compounds, providing a convenient route to the synthesis of new thyroid hormone analogues. Copyright (C) 1998 Elsevier Science Ltd.