21460-89-9

Basic information

• Product Name: 2-hydroxy-5-phenylazobenzoic acid methyl ester
• Synonyms: 2-hydroxy-5-phenylazobenzoic acid methyl ester
• CAS NO: 21460-89-9
• Molecular Weight: 256.261
• Mol File: 21460-89-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-5-phenylazobenzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-5-phenylazobenzoic acid methyl ester(21460-89-9)
• EPA Substance Registry System: 2-hydroxy-5-phenylazobenzoic acid methyl ester(21460-89-9)

Safety Data

• Hazardous Substances Data: 21460-89-9(Hazardous Substances Data)

Upstream product

• 69-72-7 salicylic acid 
• 100-34-5 benzene diazonium chloride 
• 2684-02-8 benzenediazonium 
• 119-36-8 methyl salicylate 
• 67-56-1 methanol 
• 3147-53-3 2-hydroxy-5-phenylazo-benzoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 89-57-6 5-Aminosalicylic Acid 
• 16000-09-2 4,4'-Bis-(α-(4-benzolazo-2-methoxycarbonyl-phenoxy)-benzylidenamino)-azobenzol 
• 16080-25-4 N,N'-(1,5-Naphthylen)-bis-benzimidsaeure-bis-(4-benzolazo-2-methoxycarbonyl-phenylester) 
• 15926-63-3 N,N'-(2,6-Anthrachinonylen)-bis-benzimidsaeure-(4-benzolazo-2-methoxycarbonyl-phenylester) 
• 16080-26-5 N,N'-Bis-(4-benzolazo-N-benzoyl-2-methoxycarbonylanilino)azobenzol 
• 16000-07-0 N,N'-(4,4'-Biphenylylen)-bis-benzimidsaeure-bis-(4-benzolazo-2-methoxycarbonyl-phenylester) 
• 16000-05-8 N,N'-(p-Phenylen)-bis-benzimidsaeure-bis-(4-benzolazo-2-methoxycarbonyl-phenylester) 

Relevant articles and documents

Amino and chlorambucil analogues of pentamidine - Synthesis and biological examinations

The amino analogues of pentamidine with a polymethylene (n = 3-6) chain and their chlorambucil derivatives were synthesized. The obtained compounds revealed cytotoxic effect on MCF-7 human breast cancer cell line (IC 50 = 22-95 ± 2 μM), mainly by the induction of apoptosis. The topoisomerase I/II inhibition assay and the ethidium displacement assay with the use of pBR322 plasmid DNA were used to the study of mechanism by which the obtained compounds could act. All the compounds are able to bind with DNA and interfere in vitro with the activity of topoisomerase (I and II). The determination of association constants with the use of calf thymus DNA, T4 coliphage DNA, poly(dA-dT)2 and poly(dG-dC)2 showed that the tested compounds bind within minor groove of B-DNA, but not selectively. The alkylating activity of chlorambucil derivatives determined in vitro using a Preussmann test was similar to the activity of chlorambucil. The influence of all the compounds on the amidolytic activity of plasmin and trypsin was also examined. The plasmin activity was inhibited by pentamidine, chlorambucil and aromatic bis-amines (IC50 = 0.1-8 mM), whereas the trypsin activity was influenced only by pentamidine.