2146146-58-7

Basic information

• Product Name: 3-fluoro-4-[(trimethylsilyl)ethynyl]aniline
• CAS NO: 2146146-58-7
• Molecular Weight: 207.323
• Mol File: 2146146-58-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-fluoro-4-[(trimethylsilyl)ethynyl]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-4-[(trimethylsilyl)ethynyl]aniline(2146146-58-7)
• EPA Substance Registry System: 3-fluoro-4-[(trimethylsilyl)ethynyl]aniline(2146146-58-7)

Safety Data

• Hazardous Substances Data: 2146146-58-7(Hazardous Substances Data)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 656-66-6 3-fluoro-4-iodoaniline 
• 1066-54-2 trimethylsilylacetylene 

Relevant articles and documents

P -Toluenesulfonic Acid Induced Conversion of Fluorinated Trimethylsilylethynylanilines into Aminoacetophenones: Versatile Precursors for the Synthesis of Benzoazaheterocycles

A simple and efficient approach to the synthesis of fluorinated amino-substituted acetophenones in good to excellent yields is reported. The heart of the proposed method consists of conversion of a Me 3 Si-C≡C- moiety into a MeC(=O)- group in the presence of p -tolu ene sulfonic acid (p -TSA) passing a stage of ethynylaniline formation. The reaction is metal-free, proceeds under mild conditions, and uses readily available starting compounds (trimethylsilylarylacetylene derivatives). The reaction provides access to amino-substituted acetophenones, which may serve as precursors for the synthesis of polyfluorinated azaheterocycles, having potential anticarcinogenic activity.