21464-58-4Relevant articles and documents
New aromatase inhibitors. Synthesis and biological activity of aryl- substituted pyrrolizine and indolizine derivatives
Sonnet, Pascal,Dallemagne, Patrick,Guillon, Jean,Enguehard, Cecile,Stiebing, Silvia,Tanguy, Julien,Bureau, Ronan,Rault, Sylvain,Auvray, Pierrick,Moslemi, Safa,Sourdaine, Pascal,Seralini, Gilles-Eric
, p. 945 - 955 (2007/10/03)
We report herein the design and the synthesis of some aryl-substituted pyrrolizine and indolizine derivatives, on the basis of a hypothetical pharmacophore structure designed to fit the catalytic site of the human cytochrome P450 aromatase. The in vitro b