21472-33-3 Usage
Description
Mebendazole IMpurity B is a chemical compound derived from the benzimidazolone moiety, which is known for its ability to inhibit p38 MAP kinase, a protein that plays a significant role in the activation of biological factors associated with various inflammatory diseases.
Uses
Used in Pharmaceutical Industry:
Mebendazole IMpurity B is used as an active pharmaceutical ingredient for the development of drugs targeting inflammatory diseases such as psoriasis and rheumatoid arthritis. Its ability to inhibit p38 MAP kinase makes it a promising candidate for the treatment of these conditions.
Used in Research and Development:
Mebendazole IMpurity B is also utilized in research and development for the study of p38 MAP kinase inhibition and its potential applications in the treatment of other inflammatory diseases. Mebendazole IMpurity B can be used to investigate the underlying mechanisms of these conditions and to develop new therapeutic strategies.
Used in Drug Delivery Systems:
Similar to gallotannin, Mebendazole IMpurity B can be incorporated into drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Various organic and metallic nanoparticles can be employed as carriers for Mebendazole IMpurity B, aiming to improve its overall efficacy in treating inflammatory diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 21472-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,7 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 21472-33:
(7*2)+(6*1)+(5*4)+(4*7)+(3*2)+(2*3)+(1*3)=83
83 % 10 = 3
So 21472-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H10N2O2/c17-13(9-4-2-1-3-5-9)10-6-7-11-12(8-10)16-14(18)15-11/h1-8H,(H2,15,16,18)
21472-33-3Relevant articles and documents
Scope of chemical fixation of carbon dioxide catalyzed by a bifunctional monomeric tungstate
Kamata, Keigo,Kimura, Toshihiro,Sunaba, Hanako,Mizuno, Noritaka
, p. 160 - 166 (2014/03/21)
The tungsten-oxo moiety in a simple monomeric tungstate, TBA 2[WO4] (I, TBA = tetra-n-butylammonium), showed bifunctional activation of both CO2 and 1,2-phenylenediamine (1a). It was confirmed by 1H, 13C, and 183W NMR spectroscopies that adducts I-1a and I-(CO2)n (n = 1 and 2) were formed by the reactions of I with 1a and CO2, respectively. These adducts played important roles in formation of the corresponding carbamic acid intermediates. The present bifunctionality could be applied to chemical fixation of CO2 even at atmospheric pressure with various kinds of structurally diverse aryl diamines, primary monoamines, propargylic alcohols, and propargylic amines into cyclic urea derivatives, 1,3-disubstituted urea derivatives, cyclic carbonates, and cyclic carbamates, respectively.
A bifunctional tungstate catalyst for chemical fixation of CO2 at atmospheric pressure
Kimura, Toshihiro,Kamata, Keigo,Mizuno, Noritaka
supporting information; experimental part, p. 6700 - 6703 (2012/08/28)
No pressure: A simple monomeric tungstate, [WO4]2-, serves as a highly efficient homogeneous catalyst for various transformations of CO2 at atmospheric pressure. The tungsten-oxo moiety activates CO2 and the substrate simultaneously. The catalyst system is high yielding and applicable to a wide range of substrates such as amines (see scheme), 2-aminobenzonitriles, and propargylic alcohols. Copyright
