214854-34-9Relevant articles and documents
Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1,2,4-triazole derivatives their molecular docking and kinetic studies
Aboaba, Sherifat A.,Chigurupati, Sridevi,Hameed, Shehryar,Kannan Maharajan, Mari,Kanwal,Mohammed Khan, Khalid.,Perveen, Shahnaz,Shamim, Shahbaz,Taha, Muhammad,Ur Rehman, Ashfaq,Wadood, Abdul,Yeye, Emmanuel Oloruntoba
, (2020/04/23)
Thirty-three 4-amino-1,2,4-triazole derivatives 1–33 were synthesized by reacting 4-amino-1,2,4-triazole with a variety of benzaldehydes. The synthetic molecules were characterized via 1H NMR and EI-MS spectroscopic techniques and evaluated for
Substituent swap affects the crystal structure and properties of: N -benzyl-4-amino-1,2,4-triazole related organic salts
Wang, Jing-Wen,Li, Yao-Jia,Chen, Chen,Luo, Yang-Hui,Sun, Bai-Wang
, p. 13846 - 13854 (2017/11/27)
An investigation into the effect of switching methoxy and hydroxyl groups on molecular salts is presented in this study. The salts HL1+·NO3- (1), L1·HL1+·ClO4- (2), L1·HL1+·H2PO4-·H2O (3), HL2+·NO3- (4), HL2+·ClO4- (5) and HL2+·H2PO4- (6) were synthesized and structurally characterized. The study was carried out by analyzing the crystal structure, properties and intermolecular interactions within each of the salts using IR and fluorescence spectra, TGA, Hirshfeld surface analyses and π?π stacking motifs. Salt 1 has a layered structure, while 4 has a distorted 3-D structure. Salt 2 possesses an edge-to-face type plane interaction, while 5 is formed with a twisted structure. It is important to note that water molecules play a key role in the 1-D chain structure of salt 3. The π?π stacking motif of salts 1-3 have a herringbone structure, while salts 3-6 exhibit a γ-structure. In addition, the competitive crystallization of the synthetic salts was investigated and found to be consistent with the measured solubility.
Synthesis and biological activity of 3-[4H-(1,2,4)-triazolyl]-2-aryl-1,3- thiazolidin-4-ones
Patel,Patel
experimental part, p. 2391 - 2398 (2009/08/07)
4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2 a-h) in good yields. Cyclocondensation of compounds (2 a-h) with thioglycolic acid yields 3-[4H-(1,2,4)