21487-49-0

Basic information

• Product Name: 3-(4-NITRO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• Synonyms: 3-(4-nitrophenyl)-1-phenylpyrazole-4-carbaldehyde
• CAS NO: 21487-49-0
• Molecular Formula: C₁₆H₁₁N₃O₃
• Molecular Weight: 293.28
• Mol File: 21487-49-0.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 511.9°Cat760mmHg
• Flash Point: 263.4°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 1.36E-10mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 3-(4-NITRO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-NITRO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(21487-49-0)
• EPA Substance Registry System: 3-(4-NITRO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(21487-49-0)

Safety Data

• Hazardous Substances Data: 21487-49-0(Hazardous Substances Data)

Usage

General Description

3-(4-NITRO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE is a chemical compound with the molecular formula C18H12N4O3. It is a derivative of pyrazole and contains a nitrophenyl and phenyl group. 3-(4-NITRO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE is a yellow solid that is commonly used in organic synthesis and medicinal chemistry. It has applications in the development of pharmaceuticals and agrochemicals due to its potential as a building block for various biologically active compounds. 3-(4-NITRO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE is also known for its ability to act as a fluorescent probe for the detection of nitroreductase in tumor cells, making it important in cancer research.

InChI:InChI=1/C16H11N3O3/c20-11-13-10-18(14-4-2-1-3-5-14)17-16(13)12-6-8-15(9-7-12)19(21)22/h1-11H

Upstream product

• 98-86-2 acetophenone 
• 100-16-3 4-nitrophenylhydrazone 
• 68-12-2 N,N-dimethyl-formamide 
• 20147-63-1 3-(4-nitrophenyl)-1-phenyl-1H-pyrazole 
• 77635-72-4 (E)?1-(1-(4-nitrophenyl)ethylidene)-2-phenylhydrazine 
• 100-63-0 phenylhydrazine 
• 100-19-6 (4-nitrophenyl)ethanone 
• 59-88-1 phenylhydrazine hydrochloride 
• 2675-22-1 acetophenone p-nitrophenylhydrazone 
• 77635-72-4 1-(4-nitro-phenyl)-ethanone-phenylhydrazone 

Downstream Products

• 1380571-35-6 3-(4-nitrophenyl)-N,1-diphenyl-1H-pyrazole-4-carboxamide 
• 1380571-36-7 N-(4-chlorophenyl)-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxamide 
• 1380571-37-8 N-(4-bromophenyl)-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxamide 
• 1380571-38-9 N-(4-methoxylphenyl)-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxamide 
• 1380571-39-0 N-(4-ethoxyphenyl)-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxamide 
• 77169-13-2 3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 1421332-51-5 1-((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methyleneamino)-2-butylisothiourea 
• 1421332-49-1 1-((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methyleneamino)-2-ethylisothiourea 
• 1421332-58-2 3-((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methyleneamino)-1-ethyl-2-thioxoimidazolidin-4-one 
• 1421332-50-4 1-((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methyleneamino)-2-propylisothiourea 
• 1495773-30-2 C₂₅H₁₇N₃O₃ 
• 1495773-23-3 C₃₁H₂₀N₄O₂S 

Relevant articles and documents

1,3,4-Trisubstituted pyrazole analogues as promising anti-inflammatory agents

Twenty-two 1,3,4-trisubstituted pyrazole (3a-d), (4a-d), (5a-d), (6a-l) derivatives were synthesized and structure of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectral analysis. These compounds

H3PO4 catalyzed one-pot synthesis of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde to novel 1,3-diphenyl-1H-pyrazole-4-carbonitrile

Abstract: One-pot condensation of pyrazole-4-aldehydes and hydroxylamine hydrochloride to form the corresponding oxime using formic acid as a medium and further dehydration of oxime using a catalytic amount of orthophosphoric acid to afford novel pyrazole-4-carbonitrile. This protocol serves as an ortho-phosphoric acid-catalyzed one-pot conversion of aldehyde to nitrile. Most remarkable features of this method are metal-free, cost-effective, atom efficiency with excellent yield (98–99%). This process will serve as a robust and scalable tool for the synthesis of valuable and versatile precursor (nitriles). This precursor will pave the way for the synthesis of various medicinally important valuable compounds. Graphic abstract: [Figure not available: see fulltext.].

Synthesis, biological evaluation, and molecular docking studies of novel pyrazole, pyrazoline-clubbed pyridine as potential antimicrobial agents

We have prepared 15 hybrid pyrazole, pyrazoline-clubbed pyridine–containing compounds (5a-o) and tested for their antibacterial and antifungal activities for the development of potential antimicrobial agents. The structures of this novel series were chara